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A few cases of colorectal, pancreatic, testis and stomach cancer showed moderate cytoplasmic positivity. Most remaining cancer tissues were weakly stained or negative.
Several cases of melanomas, colorectal, ovarian, lung cancers along with few endometrial, urothelial, stomach cancers and hepatocellular carcinomas showed moderate to strong cytoplasmic immunoreactivity. Other cancer tissues were in general weakly stained or negative.
GENE INFORMATION
Gene name
NOCT (HGNC Symbol)
Synonyms
Ccr4c, CCR4L, CCRN4L, NOC
Description
Nocturnin (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector. [provided by RefSeq, Jul 2008]