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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CACNA1C
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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

CACNA1C

Gene descriptioni

Gene description according to HGNC.

Calcium channel, voltage-dependent, L type, alpha 1C subunit

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular,Membrane

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

32
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (HDLM-2)
HPA (normal tissue):Tissue enhanced (smooth muscle)

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Membranous expression mainly in smooth muscle, endothelium and heart.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly consistent with RNA expression data.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Supported based on 1 antibody.
HPA039796
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Mixed

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

HPA039796

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

A few cases of renal cancers exhibited moderate cytoplasmic and membranous positivity. Endothelial cells were distinctly stained. Other malignant tissues were in general negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

CACNA1C (HGNC Symbol)

Synonyms

CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS

Description

Calcium channel, voltage-dependent, L type, alpha 1C subunit (HGNC Symbol)

Entrez gene summary

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]

Chromosome

12

Cytoband

p13.33

Chromosome location (bp)

1970786 - 2697950

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151067 (version 83.38)

Entrez gene

775

UniProt

Q13936 (UniProt - Evidence at protein level)

neXtProt

NX_Q13936

Antibodypedia

CACNA1C antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

«
CACNA1C-001
CACNA1C-002
CACNA1C-003
CACNA1C-004
CACNA1C-005
CACNA1C-006
CACNA1C-007
CACNA1C-008
CACNA1C-010
CACNA1C-011
CACNA1C-012
CACNA1C-013
CACNA1C-015
CACNA1C-016
CACNA1C-017
CACNA1C-018
CACNA1C-019
CACNA1C-020
CACNA1C-021
CACNA1C-022
CACNA1C-023
CACNA1C-024
CACNA1C-026
CACNA1C-031
CACNA1C-032
CACNA1C-034
CACNA1C-036
CACNA1C-201
CACNA1C-202
CACNA1C-203
CACNA1C-204
CACNA1C-205
»

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CACNA1C-001
ENSP00000382563
ENST00000399655
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2138 aa
239.6 kDa
No >9
CACNA1C-002
ENSP00000382504
ENST00000399595
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2146 aa
240.4 kDa
No >9
CACNA1C-003
ENSP00000382552
ENST00000399644
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2138 aa
239.5 kDa
No >9
CACNA1C-004
ENSP00000382547
ENST00000399638
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2166 aa
242.8 kDa
No >9
CACNA1C-005
ENSP00000382506
ENST00000399597
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2138 aa
239.7 kDa
No >9
CACNA1C-006
ENSP00000382530
ENST00000399621
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2157 aa
241.6 kDa
No >9
CACNA1C-007
ENSP00000382546
ENST00000399637
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2157 aa
241.5 kDa
No >9
CACNA1C-008
ENSP00000382500
ENST00000399591
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2146 aa
240.3 kDa
No >9
CACNA1C-010
ENSP00000382549
ENST00000399641
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2138 aa
239.5 kDa
No >9
CACNA1C-011
ENSP00000382512
ENST00000399603
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2138 aa
239.7 kDa
No >9
CACNA1C-012
ENSP00000382542
ENST00000399634
E9PDI6 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2209 aa
247.1 kDa
No >9
CACNA1C-013
ENSP00000382526
ENST00000399617
A0A0A0MSA1 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2173 aa
243.7 kDa
No >9
CACNA1C-015
ENSP00000336982
ENST00000335762
F5H522 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2163 aa
242.4 kDa
No >9
CACNA1C-016
ENSP00000478996
ENST00000465278
A0A087WUX4 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0034220 [ion transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
243 aa
27 kDa
No 2
CACNA1C-017
ENSP00000266376
ENST00000347598
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0002095 [caveolar macromolecular signaling complex]
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006939 [smooth muscle contraction]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0007628 [adult walking behavior]
GO:0008217 [regulation of blood pressure]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0008542 [visual learning]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017156 [calcium ion-dependent exocytosis]
GO:0019229 [regulation of vasoconstriction]
GO:0030018 [Z disc]
GO:0030073 [insulin secretion]
GO:0030252 [growth hormone secretion]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0042593 [glucose homeostasis]
GO:0043025 [neuronal cell body]
GO:0043198 [dendritic shaft]
GO:0044281 [small molecule metabolic process]
GO:0046620 [regulation of organ growth]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060083 [smooth muscle contraction involved in micturition]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2186 aa
245 kDa
No >9
CACNA1C-018
ENSP00000437936
ENST00000480911
F5H638 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
1279 aa
144.7 kDa
No >9
CACNA1C-019
ENSP00000382515
ENST00000399606
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2158 aa
241.9 kDa
No >9
CACNA1C-020
ENSP00000382510
ENST00000399601
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2138 aa
239.5 kDa
No >9
CACNA1C-021
ENSP00000341092
ENST00000344100
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2179 aa
243.7 kDa
No >9
CACNA1C-022
ENSP00000382537
ENST00000399629
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2155 aa
241.5 kDa
No >9
CACNA1C-023
ENSP00000329877
ENST00000327702
A0A0A0MR67 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2173 aa
243.5 kDa
No >9
CACNA1C-024
ENSP00000382557
ENST00000399649
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2144 aa
240.2 kDa
No >9
CACNA1C-026
ENSP00000479274
ENST00000496818
A0A087WV93 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0034220 [ion transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
144 aa
17.3 kDa
No 2
CACNA1C-031
ENSP00000385896
ENST00000406454
F5GY28 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2209 aa
247.2 kDa
No >9
CACNA1C-032
ENSP00000385724
ENST00000402845
Q13936 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Calcium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006112 [energy reserve metabolic process]
GO:0006811 [ion transport]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007411 [axon guidance]
GO:0008331 [high voltage-gated calcium channel activity]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030018 [Z disc]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0035585 [calcium-mediated signaling using extracellular calcium source]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0050796 [regulation of insulin secretion]
GO:0051393 [alpha-actinin binding]
GO:0055085 [transmembrane transport]
GO:0060402 [calcium ion transport into cytosol]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
Show all
2157 aa
241.6 kDa
No >9
CACNA1C-034
ENSP00000445849
ENST00000543114
F5H0X0 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted intracellular proteins
Show all
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0034220 [ion transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
100 aa
10.4 kDa
No 0
CACNA1C-036
ENSP00000482910
ENST00000616390
A0A087WZV3 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
829 aa
91.5 kDa
No 3
CACNA1C-201
ENSP00000483335
ENST00000613940
A0A087X0E8 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2014 aa
226.5 kDa
No >9
CACNA1C-202
ENSP00000480922
ENST00000615303
A0A087WXD3 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2062 aa
231.8 kDa
No >9
CACNA1C-203
ENSP00000480292
ENST00000615400
A0A087WWK5 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2027 aa
227.9 kDa
No >9
CACNA1C-204
ENSP00000479029
ENST00000620878
A0A087WUZ0 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2039 aa
228.8 kDa
No >9
CACNA1C-205
ENSP00000484796
ENST00000621625
A0A087X293 [Direct mapping]
Voltage-dependent L-type calcium channel subunit alpha-1C
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005245 [voltage-gated calcium channel activity]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006811 [ion transport]
GO:0016020 [membrane]
GO:0034220 [ion transmembrane transport]
GO:0034765 [regulation of ion transmembrane transport]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0086010 [membrane depolarization during action potential]
Show all
2014 aa
226.3 kDa
No >9

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