Expression of CACNA1C in cancer - Summary

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	CACNA1C
Gene descriptionⁱ Gene description according to HGNC.	Calcium channel, voltage-dependent, L type, alpha 1C subunit
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Disease related genes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	32
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (HDLM-2)
HPA (normal tissue):	Tissue enhanced (smooth muscle)

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Membranous expression mainly in smooth muscle, endothelium and heart.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining mainly consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 1 antibody. HPA039796
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

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RNA cancer category: Mixed

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA039796

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CACNA1C (HGNC Symbol)
Synonyms	CACH2, CACN2, CACNL1A1, Cav1.2, CCHL1A1, LQT8, TS
Description	Calcium channel, voltage-dependent, L type, alpha 1C subunit (HGNC Symbol)
Entrez gene summary	This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits. [provided by RefSeq, Oct 2012]
Chromosome	12
Cytoband	p13.33
Chromosome location (bp)	1970786 - 2697950
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151067 (version 83.38)
Entrez gene	775
UniProt	Q13936 (UniProt - Evidence at protein level)
neXtProt	NX_Q13936
Antibodypedia	CACNA1C antibodies

PROTEIN BROWSERⁱ

CACNA1C-001	CACNA1C-002	CACNA1C-003	CACNA1C-004	CACNA1C-005	CACNA1C-006	CACNA1C-007	CACNA1C-008	CACNA1C-010	CACNA1C-011	CACNA1C-012	CACNA1C-013	CACNA1C-015	CACNA1C-016	CACNA1C-017	CACNA1C-018	CACNA1C-019	CACNA1C-020	CACNA1C-021	CACNA1C-022	CACNA1C-023	CACNA1C-024	CACNA1C-026	CACNA1C-031	CACNA1C-032	CACNA1C-034	CACNA1C-036	CACNA1C-201	CACNA1C-202	CACNA1C-203	CACNA1C-204	CACNA1C-205

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CACNA1C-001 ENSP00000382563 ENST00000399655	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2138 aa 239.6 kDa	No	>9
CACNA1C-002 ENSP00000382504 ENST00000399595	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2146 aa 240.4 kDa	No	>9
CACNA1C-003 ENSP00000382552 ENST00000399644	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2138 aa 239.5 kDa	No	>9
CACNA1C-004 ENSP00000382547 ENST00000399638	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2166 aa 242.8 kDa	No	>9
CACNA1C-005 ENSP00000382506 ENST00000399597	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2138 aa 239.7 kDa	No	>9
CACNA1C-006 ENSP00000382530 ENST00000399621	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2157 aa 241.6 kDa	No	>9
CACNA1C-007 ENSP00000382546 ENST00000399637	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2157 aa 241.5 kDa	No	>9
CACNA1C-008 ENSP00000382500 ENST00000399591	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2146 aa 240.3 kDa	No	>9
CACNA1C-010 ENSP00000382549 ENST00000399641	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2138 aa 239.5 kDa	No	>9
CACNA1C-011 ENSP00000382512 ENST00000399603	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2138 aa 239.7 kDa	No	>9
CACNA1C-012 ENSP00000382542 ENST00000399634	E9PDI6 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2209 aa 247.1 kDa	No	>9
CACNA1C-013 ENSP00000382526 ENST00000399617	A0A0A0MSA1 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2173 aa 243.7 kDa	No	>9
CACNA1C-015 ENSP00000336982 ENST00000335762	F5H522 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2163 aa 242.4 kDa	No	>9
CACNA1C-016 ENSP00000478996 ENST00000465278	A0A087WUX4 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0034220 [ion transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	243 aa 27 kDa	No	2
CACNA1C-017 ENSP00000266376 ENST00000347598	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0002095 [caveolar macromolecular signaling complex] GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0006939 [smooth muscle contraction] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007268 [synaptic transmission] GO:0007411 [axon guidance] GO:0007628 [adult walking behavior] GO:0008217 [regulation of blood pressure] GO:0008331 [high voltage-gated calcium channel activity] GO:0008542 [visual learning] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017156 [calcium ion-dependent exocytosis] GO:0019229 [regulation of vasoconstriction] GO:0030018 [Z disc] GO:0030073 [insulin secretion] GO:0030252 [growth hormone secretion] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0042593 [glucose homeostasis] GO:0043025 [neuronal cell body] GO:0043198 [dendritic shaft] GO:0044281 [small molecule metabolic process] GO:0046620 [regulation of organ growth] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060083 [smooth muscle contraction involved in micturition] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2186 aa 245 kDa	No	>9
CACNA1C-018 ENSP00000437936 ENST00000480911	F5H638 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	1279 aa 144.7 kDa	No	>9
CACNA1C-019 ENSP00000382515 ENST00000399606	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2158 aa 241.9 kDa	No	>9
CACNA1C-020 ENSP00000382510 ENST00000399601	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2138 aa 239.5 kDa	No	>9
CACNA1C-021 ENSP00000341092 ENST00000344100	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2179 aa 243.7 kDa	No	>9
CACNA1C-022 ENSP00000382537 ENST00000399629	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2155 aa 241.5 kDa	No	>9
CACNA1C-023 ENSP00000329877 ENST00000327702	A0A0A0MR67 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2173 aa 243.5 kDa	No	>9
CACNA1C-024 ENSP00000382557 ENST00000399649	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2144 aa 240.2 kDa	No	>9
CACNA1C-026 ENSP00000479274 ENST00000496818	A0A087WV93 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0034220 [ion transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	144 aa 17.3 kDa	No	2
CACNA1C-031 ENSP00000385896 ENST00000406454	F5GY28 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2209 aa 247.2 kDa	No	>9
CACNA1C-032 ENSP00000385724 ENST00000402845	Q13936 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Transporters Transporter channels and pores Voltage-gated ion channels Voltage-Gated Calcium Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005891 [voltage-gated calcium channel complex] GO:0006112 [energy reserve metabolic process] GO:0006811 [ion transport] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007411 [axon guidance] GO:0008331 [high voltage-gated calcium channel activity] GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030018 [Z disc] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035585 [calcium-mediated signaling using extracellular calcium source] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0050796 [regulation of insulin secretion] GO:0051393 [alpha-actinin binding] GO:0055085 [transmembrane transport] GO:0060402 [calcium ion transport into cytosol] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] GO:0086064 [cell communication by electrical coupling involved in cardiac conduction] Show all	2157 aa 241.6 kDa	No	>9
CACNA1C-034 ENSP00000445849 ENST00000543114	F5H0X0 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted intracellular proteins Show all	GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0034220 [ion transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	100 aa 10.4 kDa	No	0
CACNA1C-036 ENSP00000482910 ENST00000616390	A0A087WZV3 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	829 aa 91.5 kDa	No	3
CACNA1C-201 ENSP00000483335 ENST00000613940	A0A087X0E8 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2014 aa 226.5 kDa	No	>9
CACNA1C-202 ENSP00000480922 ENST00000615303	A0A087WXD3 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2062 aa 231.8 kDa	No	>9
CACNA1C-203 ENSP00000480292 ENST00000615400	A0A087WWK5 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2027 aa 227.9 kDa	No	>9
CACNA1C-204 ENSP00000479029 ENST00000620878	A0A087WUZ0 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2039 aa 228.8 kDa	No	>9
CACNA1C-205 ENSP00000484796 ENST00000621625	A0A087X293 [Direct mapping] Voltage-dependent L-type calcium channel subunit alpha-1C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005245 [voltage-gated calcium channel activity] GO:0005891 [voltage-gated calcium channel complex] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070509 [calcium ion import] GO:0070588 [calcium ion transmembrane transport] GO:0086010 [membrane depolarization during action potential] Show all	2014 aa 226.3 kDa	No	>9