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Most cancer tissues showed weak to moderate cytoplasmic staining with additional luminal membranous positivity in some cases. A few casese of prostate cancer showed strong immunoreactivity. Lymphomas, melanomas, renal cell carcinomas along with several cases of gliomas, urothelial, ovarian and cervical cancers were negative.
GENE INFORMATION
Gene name
SAV1 (HGNC Symbol)
Synonyms
salvador, WW45, WWP4
Description
Salvador family WW domain containing protein 1 (HGNC Symbol)
Entrez gene summary
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]