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Malignant cells generally showed weak to moderate cytoplasmic immunoreactivity. A majority of malignant lymphomas and breast cancers were negative.
GENE INFORMATION
Gene name
PTPRR (HGNC Symbol)
Synonyms
EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ
Description
Protein tyrosine phosphatase, receptor type, R (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]