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Occasional cases of prostate and liver cancer displayed strong cytoplasmic staining. Moderate cytoplasmic positivity with occasional nuclear staining was observed in a few cases of malignant lymphomas, malignant melanomas, thyroid, testis, lung and ovarian cancers. Remaining malignant cells were weakly stained or negative.
GENE INFORMATION
Gene name
GRAP
Synonyms
Description
GRB2-related adaptor protein (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012]