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Tissue enhanced (cervix, uterine, small intestine)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Membranous expression and extracellular positivity in several tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
A fraction of cancer tissues in several cases of renal cancers and a few cases of colorectal cancers showed moderate membranous staining. A subset of cancer tisssues in occasional cases of ovarian cancers showed strong positivity. Remaining cancer tissues were negative.
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Oct 2015]