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Moderate to strong cytoplasmic staining was observed in a few cases of melanomas, breast and prostate carcinomas. Remaining cancer tissues were generally negative.
Weak to moderate cytoplasmic staining, often accompanied by nucleolar positivity, was observed in most cancer tissues. Several cases of squamous cell carcinomas and endometrial cancers were negative.
GENE INFORMATION
Gene name
PANK4 (HGNC Symbol)
Synonyms
FLJ10782
Description
Pantothenate kinase 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]