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A fraction of tumor cells in several melanomas, squamous cell carcinomas, colorectal and urothelial cancers along with a few gliomas, lymphomas, pancreatic, testicular and stomach cancers displayed moderate to strong nuclear immunoreactivity. Remaining cancers tissues were negative.
GENE INFORMATION
Gene name
CHAF1B (HGNC Symbol)
Synonyms
CAF-1, CAF1, CAF1A, CAF1P60, MPHOSPH7, MPP7
Description
Chromatin assembly factor 1, subunit B (p60) (HGNC Symbol)
Entrez gene summary
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]