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Cancer tissues showed moderate nuclear immunoreactivity with additional cytoplasmic staining in some cases. Renal cancer along with several cases of gliomas and pancreatic cancer were strongly stained.
Most renal cancers and several melanomas, liver and pancreatic cancers showed moderate cytoplasmic positivity. The remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
C21orf2 (HGNC Symbol)
Synonyms
A2, LRRC76, YF5
Description
Chromosome 21 open reading frame 2 (HGNC Symbol)
Entrez gene summary
Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients. [provided by RefSeq, Sep 2012]