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Most cancer tissues displayed weak to moderate cytoplasmic staining with a granular or dotlike pattern. a few cases of colorectal cancer showed strong immunoreactivity, while most lung, testicular and renal cancers were negative.
Skin cancers, gliomas and carcinoids showed moderate to strong cytoplasmic staining while endometrial, ovarian and liver cancers showed weak to moderate staining. Remaining cancers were generally negative.
GENE INFORMATION
Gene name
FMNL3 (HGNC Symbol)
Synonyms
DKFZp762B245, MGC45819, WBP3
Description
Formin-like 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]