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Most cancer tissues exhibited moderate to strong nuclear immunoreactivity, often seen in a fraction of cells. Hepatocellular carcinomas, prostate and renal cancers were generally negative.
Most of the cancer tissues displayed weak to moderate nuclear positivity in a fraction of cells. Many gliomas, prostate, endometrial, renal and liver cancers were negative.
GENE INFORMATION
Gene name
RACGAP1 (HGNC Symbol)
Synonyms
MgcRacGAP
Description
Rac GTPase activating protein 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]