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Several cases of hepatocellular carcinomas, colorectal, thyroid and few ovarian cancers were moderately stained in the cytoplasm. Remaining cancers were weakly stained or generally negative.
Flavin-dependent histone demethylases, such as KDM1B, regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (Karytinos et al., 2009 [PubMed 19407342]).[supplied by OMIM, Oct 2009]