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A majority of cancer tissues displayed weak to moderate cytoplasmic staining. Strong immunoreactivity was observed in carcinoids and a few cases of melanomas and urothelial cancers.
Membranous staining of various intensities was observed in carcinoid. Neuropil in gliomas showed strong cytoplasmic staining. All other cancers were negative.
GENE INFORMATION
Gene name
STX3 (HGNC Symbol)
Synonyms
STX3A
Description
Syntaxin 3 (HGNC Symbol)
Entrez gene summary
The gene is a member of the syntaxin family. The encoded protein is targeted to the apical membrane of epithelial cells where it forms clusters and is important in establishing and maintaining polarity necessary for protein trafficking involving vesicle fusion and exocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]