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Moderate to strong cytoplasmic immunoreactivity was observed in most lymphomas along with few lung and pancreatic cancers. Thyroid malignancies along with few hepatocellular carcinomas, colorectal, breast, prostate and gastric cancers showed moderate cytoplasmic staining. Other cancer tissues were weakly stained or generally negative.
GENE INFORMATION
Gene name
RASSF6
Synonyms
Description
Ras association (RalGDS/AF-6) domain family member 6 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]