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RNA tissue category: Tissue enhanced (duodenum, kidney, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, kidney, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine)
GENE INFORMATION
Gene name
PDZD3 (HGNC Symbol)
Synonyms
FLJ22756, IKEPP, PDZK2
Description
PDZ domain containing 3 (HGNC Symbol)
Entrez gene summary
Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]