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Cytoplasmic expression in subsets of immune cells in several tissues, including spleen and lymph node. Distinct positivity in plasma.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Wwas weak to moderate cytoplasmic immunoreactivity was observed in a few cases of most cancers. Positivity was observed also in plasma.
GENE INFORMATION
Gene name
C1QA
Synonyms
Description
Complement component 1, q subcomponent, A chain (HGNC Symbol)
Entrez gene summary
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]