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Malignant gliomas and a few cases of testicular and pancreatic cancers displayed moderate to strong nuclear positivity. Malignant cells in general were weakly stained or negative.
GENE INFORMATION
Gene name
CBX2 (HGNC Symbol)
Synonyms
CDCA6, MGC10561
Description
Chromobox homolog 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]