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Most cancer cells showed moderate to strong cytoplasmic staining combined with membranous positivity in fractions of cases. Lymphoma, prostate and renal cancer cases were generally negative.
GENE INFORMATION
Gene name
SH3PXD2B (HGNC Symbol)
Synonyms
FLJ20831, KIAA1295
Description
SH3 and PX domains 2B (HGNC Symbol)
Entrez gene summary
This gene encodes an adapter protein that is characterized by a PX domain and four Src homology 3 domains. The encoded protein is required for podosome formation and is involved in cell adhesion and migration of numerous cell types. Mutations in this gene are the cause of Frank-ter Haar syndrome (FTHS), and also Borrone Dermato-Cardio-Skeletal (BDCS) syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]