We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancers showed moderate cytoplasmic immunoreactivity. A few cases of basal cell carcinomas, lymphomas, prostate and breast cancers were strongly stained. Most testicular, renal, gastric and liver cancers were weakly stained or negative.
GENE INFORMATION
Gene name
PACS1 (HGNC Symbol)
Synonyms
FLJ10209, KIAA1175
Description
Phosphofurin acidic cluster sorting protein 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein with a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance. [provided by RefSeq, Jul 2008]