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Non Hodgkin's lymphomas showed moderate cytoplasmic and nuclear positivity. Thyroid cancers displayed weak to moderate nuclear immunoreactivity. Other cancer tissues were negative.
GENE INFORMATION
Gene name
TBC1D10C (HGNC Symbol)
Synonyms
Carabin, EPI64C, FLJ00332
Description
TBC1 domain family, member 10C (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]