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NF2

GENERAL INFORMATION

Gene namei

 NF2

Gene descriptioni

 Neurofibromin 2 (merlin)

Protein classi

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localizationi

 Intracellular

Number of transcriptsi

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidencei

 Evidence at protein level

Protein expression
normal tissuei

 Cytoplasmic expression in most tissues. Additional nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

 Antibody staining mainly consistent with RNA expression data.

Reliability scorei

 Supported based on 2 antibodies.
HPA003097 , CAB005385
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PROGNOSTIC SUMMARYi
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi
HPA003097
CAB005385

GENE INFORMATIONi

Gene name

 NF2 (HGNC Symbol)

Synonyms

 merlin

Description

 Neurofibromin 2 (merlin) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]

Chromosome

 22

Cytoband

 q12.2

Chromosome location (bp)

 29603556 - 29698598

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000186575 (version 83.38)

Entrez gene

 4771

UniProt

 P35240 (UniProt - Evidence at protein level)

neXtProt

 NX_P35240

Antibodypedia

 NF2 antibodies

PROTEIN BROWSERi
NF2-001
NF2-003
NF2-004
NF2-005
NF2-006
NF2-007
NF2-008
NF2-009
NF2-010
NF2-201

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NF2-001
ENSP00000344666
ENST00000338641
P35240 [Direct mapping]
Merlin
A0A024R1J8 [Target identity:100%; Query identity:100%]
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001707 [mesoderm formation]
GO:0001726 [ruffle]
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0006469 [negative regulation of protein kinase activity]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007398 [ectoderm development]
GO:0007420 [brain development]
GO:0008013 [beta-catenin binding]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0014013 [regulation of gliogenesis]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019904 [protein domain specific binding]
GO:0021766 [hippocampus development]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030027 [lamellipodium]
GO:0030036 [actin cytoskeleton organization]
GO:0030175 [filopodium]
GO:0030336 [negative regulation of cell migration]
GO:0030864 [cortical actin cytoskeleton]
GO:0031527 [filopodium membrane]
GO:0031647 [regulation of protein stability]
GO:0032154 [cleavage furrow]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042127 [regulation of cell proliferation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0043005 [neuron projection]
GO:0043234 [protein complex]
GO:0043409 [negative regulation of MAPK cascade]
GO:0044297 [cell body]
GO:0045121 [membrane raft]
GO:0045177 [apical part of cell]
GO:0045202 [synapse]
GO:0045216 [cell-cell junction organization]
GO:0045597 [positive regulation of cell differentiation]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050767 [regulation of neurogenesis]
GO:0051496 [positive regulation of stress fiber assembly]
GO:0070306 [lens fiber cell differentiation]
GO:0072091 [regulation of stem cell proliferation]
GO:1900180 [regulation of protein localization to nucleus]
GO:2000177 [regulation of neural precursor cell proliferation]
Show all
 595 aa
69.7 kDa 		No 0
NF2-003
ENSP00000384797
ENST00000403999
P35240 [Direct mapping]
Merlin
A0A024R1J9 [Target identity:100%; Query identity:100%]
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_e
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 590 aa
69.1 kDa 		No 0
NF2-004
ENSP00000384029
ENST00000403435
P35240 [Direct mapping]
Merlin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 561 aa
65.4 kDa 		No 0
NF2-005
ENSP00000340626
ENST00000353887
P35240 [Direct mapping]
Merlin
A0A024R1D9 [Target identity:100%; Query identity:100%]
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_d
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 507 aa
59.1 kDa 		No 0
NF2-006
ENSP00000355183
ENST00000361676
P35240 [Direct mapping]
Merlin
A0A024R1I0 [Target identity:100%; Query identity:100%]
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_g
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 548 aa
64 kDa 		No 0
NF2-007
ENSP00000354529
ENST00000361166
P35240 [Direct mapping]
Merlin
A0A024R1J9 [Target identity:100%; Query identity:100%]
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_e
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 590 aa
69.1 kDa 		No 0
NF2-008
ENSP00000335652
ENST00000334961
P35240 [Direct mapping]
Merlin
A0A024R1D9 [Target identity:100%; Query identity:100%]
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_d
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 507 aa
59.1 kDa 		No 0
NF2-009
ENSP00000380891
ENST00000397789
P35240 [Direct mapping]
Merlin
A0A024R1J9 [Target identity:100%; Query identity:100%]
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_e
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 590 aa
69.1 kDa 		No 0
NF2-010
ENSP00000354897
ENST00000361452
P35240 [Direct mapping]
Merlin
A0A024R1F6 [Target identity:100%; Query identity:100%]
Neurofibromin 2 (Bilateral acoustic neuroma), isoform CRA_i
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008092 [cytoskeletal protein binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 549 aa
64.2 kDa 		No 0
NF2-201
ENSP00000409921
ENST00000413209
P35240 [Direct mapping]
Merlin
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Splicing Mutations
   COSMIC Somatic Mutations
   COSMIC Other Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Large Deletions
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001953 [negative regulation of cell-matrix adhesion]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005769 [early endosome]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008156 [negative regulation of DNA replication]
GO:0008285 [negative regulation of cell proliferation]
GO:0014010 [Schwann cell proliferation]
GO:0016020 [membrane]
GO:0019898 [extrinsic component of membrane]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030036 [actin cytoskeleton organization]
GO:0030336 [negative regulation of cell migration]
GO:0031527 [filopodium membrane]
GO:0032587 [ruffle membrane]
GO:0035330 [regulation of hippo signaling]
GO:0042518 [negative regulation of tyrosine phosphorylation of Stat3 protein]
GO:0042524 [negative regulation of tyrosine phosphorylation of Stat5 protein]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051496 [positive regulation of stress fiber assembly]
Show all
 165 aa
19.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.