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Several liver cancer tissues and a few pancreatic cancer tissues showed moderate nuclear positivity. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
ESPN (HGNC Symbol)
Synonyms
DFNB36
Description
Espin (HGNC Symbol)
Entrez gene summary
This gene encodes a multifunctional actin-bundling protein. It plays a major role in regulating the organization, dimensions, dynamics, and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in various mechanosensory and chemosensory cells. Mutations in this gene are associated with autosomal recessive neurosensory deafness, and autosomal dominant sensorineural deafness without vestibular involvement. [provided by RefSeq, Nov 2009]