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Mainly localized to the nucleus but excluded from the nucleoli. In addition localized to the Golgi apparatus in human cells. Localized to nucleus in mouse cells.
RNA cell category
Expressed in all
Protein evidence
Evidence at protein level
Main location
Localized to the Nucleoplasm (supported)
Additional location
In addition localized to the Golgi apparatus (approved)
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
HUMAN CELLS
Summary
Mainly localized to the nucleus but excluded from the nucleoli. In addition localized to the Golgi apparatus in human cells. Localized to nucleus in mouse cells.
Transformation/transcription domain-associated protein (HGNC Symbol)
Entrez gene summary
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
C9K0N1 [Direct mapping] Transformation/transcription domain-associated protein
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Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Protein evidence (Ezkurdia et al 2014)