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Moderate to strong cytoplasmic immunoreactivity was observed in several breast, gastric, pancreatic, thyroid and lung cancers. Colorectal cancers showed nuclear staining. Remaining cancer cells were in general negative.
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]