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Cancer tissues showed weak to moderate cytoplasmic immunoreactivity with additional membranous/nuclear staining in several cases. Few cases of duct carcinomas of breast, gliomas, cervix, stomach, pancreas and urothelial cancers displayed strong positivity.
Melanomas along with papillary adenocarcinomas of thyroid and few urothelial cancers displayed moderate, dot like cytoplasmic positivity. Several cases of endometrial cancers showed moderate cytoplasmic and membranous staining. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
TBKBP1 (HGNC Symbol)
Synonyms
KIAA0775, ProSAPiP2
Description
TBK1 binding protein 1 (HGNC Symbol)
Entrez gene summary
TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]