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Most malignancies showed weak to moderate cytoplasmic immunoreactivity with additional nuclear staining in several cases. Malignant carcinoids, endometrial cancers, squamous cell and basal cell carcinomas were generally negative.
Most malignant cells showed weak to moderate cytoplasmic and nuclear positivity. Malignant lymphomas and skin cancer were in general negative.
GENE INFORMATION
Gene name
TCTN1 (HGNC Symbol)
Synonyms
FLJ21127, JBTS13, TECT1
Description
Tectonic family member 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the tectonic family of secreted and transmembrane proteins. The orthologous gene in mouse is required for formation of most ventral cell types. It functions downstream of smoothened and rab23 to modulate hedgehog signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]