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RNA cell line category: Group enriched (U-698, Daudi, CAPAN-2, EFO-21, U-266/70)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
GENE INFORMATION
Gene name
HLA-DMB (HGNC Symbol)
Synonyms
D6S221E, RING7
Description
Major histocompatibility complex, class II, DM beta (HGNC Symbol)
Entrez gene summary
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]
GO:0002399 [MHC class II protein complex assembly] GO:0002503 [peptide antigen assembly with MHC class II protein complex] GO:0005515 [protein binding] GO:0005765 [lysosomal membrane] GO:0006955 [immune response] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019882 [antigen processing and presentation] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0023026 [MHC class II protein complex binding] GO:0031902 [late endosome membrane] GO:0042102 [positive regulation of T cell proliferation] GO:0042613 [MHC class II protein complex] GO:2001190 [positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell]