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A majority of cancers exhibited moderate cytoplasmic positivity, often combined with nuclear staining. Several cases of cervical and hepatocellular carcinomas were negative.
GENE INFORMATION
Gene name
RABL6
Synonyms
Description
RAB, member RAS oncogene family-like 6 (EntrezGene)
Entrez gene summary
This gene encodes a member of the Ras superfamily of small GTPases. The encoded protein binds to both GTP and GDP and may play a role in cell growth and survival. Overexpression of this gene may play a role in breast cancer tumorigenesis, and pseudogenes of this gene are located on the long arm of chromosome 2 and the short arm of chromosome 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]