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The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Q6P1M3 [Direct mapping] Lethal(2) giant larvae protein homolog 2
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001890 [placenta development] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006887 [exocytosis] GO:0008593 [regulation of Notch signaling pathway] GO:0009791 [post-embryonic development] GO:0016332 [establishment or maintenance of polarity of embryonic epithelium] GO:0017137 [Rab GTPase binding] GO:0022008 [neurogenesis] GO:0030165 [PDZ domain binding] GO:0030864 [cortical actin cytoskeleton] GO:0030866 [cortical actin cytoskeleton organization] GO:0032878 [regulation of establishment or maintenance of cell polarity] GO:0035264 [multicellular organism growth] GO:0043231 [intracellular membrane-bounded organelle] GO:0043547 [positive regulation of GTPase activity] GO:0050708 [regulation of protein secretion] GO:0051294 [establishment of spindle orientation] GO:0051301 [cell division] GO:0060670 [branching involved in labyrinthine layer morphogenesis] GO:0060716 [labyrinthine layer blood vessel development]
Q6P1M3 [Direct mapping] Lethal(2) giant larvae protein homolog 2
Show all
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)