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PLD1

GENERAL INFORMATION

Gene name

 PLD1

Gene description

 Phospholipase D1, phosphatidylcholine-specific

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (gallbladder)
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression at variable levels in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA042396 , CAB004527
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Tonsil
N/A
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Esophagus
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PLD1

Synonyms

Description

 Phospholipase D1, phosphatidylcholine-specific (HGNC Symbol)

Entrez gene summary

 This gene encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties. [provided by RefSeq, Sep 2011]

Chromosome

 3

Cytoband

 q26.31

Chromosome location (bp)

 171600405 - 171810950

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000075651 (version 83.38)

Entrez gene

 5337

UniProt

 Q13393 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13393

Antibodypedia

 PLD1 antibodies

PROTEIN BROWSER
PLD1-001
PLD1-002
PLD1-003
PLD1-010
PLD1-201
PLD1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PLD1-001
ENSP00000342793
ENST00000351298
Q13393 [Direct mapping]
Phospholipase D1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003824 [catalytic activity]
GO:0004630 [phospholipase D activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0006643 [membrane lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006655 [phosphatidylglycerol biosynthetic process]
GO:0006887 [exocytosis]
GO:0006935 [chemotaxis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0009395 [phospholipid catabolic process]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030139 [endocytic vesicle]
GO:0030334 [regulation of cell migration]
GO:0031902 [late endosome membrane]
GO:0032534 [regulation of microvillus assembly]
GO:0035091 [phosphatidylinositol binding]
GO:0044281 [small molecule metabolic process]
GO:0046473 [phosphatidic acid metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048017 [inositol lipid-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048870 [cell motility]
GO:0050764 [regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity]
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 1074 aa
124.2 kDa 		No 0
PLD1-002
ENSP00000348681
ENST00000356327
Q13393 [Direct mapping]
Phospholipase D1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0003824 [catalytic activity]
GO:0004630 [phospholipase D activity]
GO:0005515 [protein binding]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005794 [Golgi apparatus]
GO:0006643 [membrane lipid metabolic process]
GO:0006644 [phospholipid metabolic process]
GO:0006654 [phosphatidic acid biosynthetic process]
GO:0006655 [phosphatidylglycerol biosynthetic process]
GO:0006887 [exocytosis]
GO:0006935 [chemotaxis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0009395 [phospholipid catabolic process]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0030139 [endocytic vesicle]
GO:0030334 [regulation of cell migration]
GO:0031902 [late endosome membrane]
GO:0032534 [regulation of microvillus assembly]
GO:0035091 [phosphatidylinositol binding]
GO:0044281 [small molecule metabolic process]
GO:0046473 [phosphatidic acid metabolic process]
GO:0046474 [glycerophospholipid biosynthetic process]
GO:0048017 [inositol lipid-mediated signaling]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048870 [cell motility]
GO:0050764 [regulation of phagocytosis]
GO:0060627 [regulation of vesicle-mediated transport]
GO:0070290 [N-acylphosphatidylethanolamine-specific phospholipase D activity]
Show all
 1036 aa
119.7 kDa 		No 0
PLD1-003
ENSP00000395556
ENST00000446289
H7C0L3 [Direct mapping]
Phospholipase D1
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
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 234 aa
26.2 kDa 		No 0
PLD1-010
ENSP00000400639
ENST00000418087
C9IY79 [Direct mapping]
Phospholipase D1
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0035091 [phosphatidylinositol binding]
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 142 aa
16.6 kDa 		No 0
PLD1-201
ENSP00000328422
ENST00000331659
Q8WYW5 [Direct mapping]
Phospholipase D1; Putative uncharacterized protein pp13439
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
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 152 aa
16.5 kDa 		No 0
PLD1-202
ENSP00000486967
ENST00000627725
F8WBV7 [Direct mapping]
Phospholipase D1
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 57 aa
6.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.