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Gene name

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In atlas

Reliability

Reliability

Reliability

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Method

Validation

Method

Validation

Method

Validation

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Searches

Tissue

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Expression

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Specificity

Cell line

Specificity

Cancer

Specificity

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Detectable

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ABL1
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    TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

ABL1

Gene descriptioni

Gene description according to HGNC.

ABL proto-oncogene 1, non-receptor tyrosine kinase

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Intracellular

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

Read more

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expressioni

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Cytoplasmic and nuclear expression at variable levels in all tissues.

DATA RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly consistent with RNA expression data.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Supported based on 4 antibodies.
HPA027251 , HPA027280 , HPA028409 , CAB002686
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARYi

Below is an overview of RNA and protein expression data generated in the Human Protein Atlas project. Analyzed tissues are divided into color-coded groups according to which functional features they have in common. For each group, a list of included tissues is accessed by clicking on group name, group symbol, RNA bar, or protein bar. Subsequent selection of a particular tissue in this list links to the image data page. Images of selected tissues give a visual summary of the protein expression profile furthest to the right. The gray human body provides links to a histology dictionary when clicking on any part of the figure.

RNA expression (TPM)i
RNA-seq results generated in HPA are reported as number of transcripts per million (TPM). Each bar represents the highest expression score found in a particular group of tissues. The assay is described more in detail in Assays & Annotation.
Protein expression (score)i
Each bar represents the highest expression score found in a particular group of tissues. Protein expression scores are based on a best estimate of the "true" protein expression from a knowledge-based annotation, described more in detail under Assays & annotation. For genes where more than one antibody has been used, a collective score is set displaying the estimated true protein expression.

Read more
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEWi

Protein expression data is shown for each of the 44 tissues. The color-coding is based on tissues with functional features in common. Mouse-over function shows protein score for analyzed cell types found in a selected tissue. To access image data click on tissue name or bar. Annotation of protein expression is described in detail in Assays & annotation.

For genes with available protein data for which a knowledge-based annotation gave inconclusive results, no protein expression data is displayed in the protein expression data overview, however, all immunohistochemical images are still available and the annotation data can be found under Primary data.

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-data from three different sources: Internally generated Human Protein Atlas (HPA) RNA-seq data, RNA-seq data from the Genotype-Tissue Expression (GTEx) project and CAGE data from FANTOM5 project. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.

HPA dataseti

HPA dataset
RNA-seq tissue data is reported as mean TPM (transcripts per million), corresponding to mean values of the different individual samples from each tissue. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar. The RNA-seq assay is described in detail in Assays & Annotation.

RNA tissue category HPA
HPA RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataseti

GTEx dataset
RNA-seq data are reported as median RPKM (reads per kilobase per million mapped reads), generated by the Genotype-Tissue Expression (GTEx) project. More information can be found in Assays & Annotation.

RNA tissue category GTEx
GTEx RNA tissue category (category description) is calculated based on mRNA expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataseti

FANTOM5 dataset
Tissue data obtained through Cap Analysis of Gene Expression (CAGE) are reported as Tags Per Million, generated by the FANTOM5 project. More information can be found in Assays & Annotation.

RNA tissue category FANTOM5
FANTOM5 RNA tissue category (category description) is calculated based on gene expression levels across all tissues and include: tissue enriched, group enriched, tissue enhanced, expressed in all, mixed and not detected.
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

ABL1 (HGNC Symbol)

Synonyms

ABL, c-ABL, JTK7, p150

Description

ABL proto-oncogene 1, non-receptor tyrosine kinase (HGNC Symbol)

Entrez gene summary

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

Chromosome

9

Cytoband

q34.12

Chromosome location (bp)

130713946 - 130887675

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000097007 (version 83.38)

Entrez gene

25

UniProt

P00519 (UniProt - Evidence at protein level)

neXtProt

NX_P00519

Antibodypedia

ABL1 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

ABL1-001
ABL1-002
ABL1-003

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABL1-001
ENSP00000323315
ENST00000318560
P00519 [Direct mapping]
Tyrosine-protein kinase ABL1
A0A024R8E2 [Target identity:100%; Query identity:100%]
Non-specific protein-tyrosine kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0003677 [DNA binding]
GO:0003785 [actin monomer binding]
GO:0004515 [nicotinate-nucleotide adenylyltransferase activity]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006298 [mismatch repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006914 [autophagy]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007050 [cell cycle arrest]
GO:0007067 [mitotic nuclear division]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010506 [regulation of autophagy]
GO:0015629 [actin cytoskeleton]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019905 [syntaxin binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030516 [regulation of axon extension]
GO:0031113 [regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031965 [nuclear membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034599 [cellular response to oxidative stress]
GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042127 [regulation of cell proliferation]
GO:0042692 [muscle cell differentiation]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051882 [mitochondrial depolarization]
GO:0070064 [proline-rich region binding]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:1900275 [negative regulation of phospholipase C activity]
GO:1903351 [cellular response to dopamine]
GO:1904528 [positive regulation of microtubule binding]
GO:1904531 [positive regulation of actin filament binding]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
1130 aa
122.9 kDa
No 0
ABL1-002
ENSP00000361423
ENST00000372348
P00519 [Direct mapping]
Tyrosine-protein kinase ABL1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Candidate cancer biomarkers
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0001922 [B-1 B cell homeostasis]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002322 [B cell proliferation involved in immune response]
GO:0002333 [transitional one stage B cell differentiation]
GO:0003677 [DNA binding]
GO:0003785 [actin monomer binding]
GO:0004515 [nicotinate-nucleotide adenylyltransferase activity]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006281 [DNA repair]
GO:0006298 [mismatch repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006464 [cellular protein modification process]
GO:0006468 [protein phosphorylation]
GO:0006909 [phagocytosis]
GO:0006914 [autophagy]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0006979 [response to oxidative stress]
GO:0007050 [cell cycle arrest]
GO:0007067 [mitotic nuclear division]
GO:0007155 [cell adhesion]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0007596 [blood coagulation]
GO:0008022 [protein C-terminus binding]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0010506 [regulation of autophagy]
GO:0015629 [actin cytoskeleton]
GO:0016301 [kinase activity]
GO:0016477 [cell migration]
GO:0017124 [SH3 domain binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019904 [protein domain specific binding]
GO:0019905 [syntaxin binding]
GO:0021587 [cerebellum morphogenesis]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030035 [microspike assembly]
GO:0030036 [actin cytoskeleton organization]
GO:0030100 [regulation of endocytosis]
GO:0030145 [manganese ion binding]
GO:0030154 [cell differentiation]
GO:0030155 [regulation of cell adhesion]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0030516 [regulation of axon extension]
GO:0031113 [regulation of microtubule polymerization]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031252 [cell leading edge]
GO:0031965 [nuclear membrane]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034599 [cellular response to oxidative stress]
GO:0035791 [platelet-derived growth factor receptor-beta signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042100 [B cell proliferation]
GO:0042127 [regulation of cell proliferation]
GO:0042692 [muscle cell differentiation]
GO:0042770 [signal transduction in response to DNA damage]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043124 [negative regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045087 [innate immune response]
GO:0045184 [establishment of protein localization]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045931 [positive regulation of mitotic cell cycle]
GO:0046632 [alpha-beta T cell differentiation]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048536 [spleen development]
GO:0048538 [thymus development]
GO:0048668 [collateral sprouting]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050798 [activated T cell proliferation]
GO:0050853 [B cell receptor signaling pathway]
GO:0050885 [neuromuscular process controlling balance]
GO:0051015 [actin filament binding]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051353 [positive regulation of oxidoreductase activity]
GO:0051444 [negative regulation of ubiquitin-protein transferase activity]
GO:0051726 [regulation of cell cycle]
GO:0051882 [mitochondrial depolarization]
GO:0060020 [Bergmann glial cell differentiation]
GO:0070064 [proline-rich region binding]
GO:0070373 [negative regulation of ERK1 and ERK2 cascade]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0090135 [actin filament branching]
GO:1900042 [positive regulation of interleukin-2 secretion]
GO:1900275 [negative regulation of phospholipase C activity]
GO:1901216 [positive regulation of neuron death]
GO:1902715 [positive regulation of interferon-gamma secretion]
GO:1903053 [regulation of extracellular matrix organization]
GO:1903351 [cellular response to dopamine]
GO:1904528 [positive regulation of microtubule binding]
GO:1904531 [positive regulation of actin filament binding]
GO:2000096 [positive regulation of Wnt signaling pathway, planar cell polarity pathway]
GO:2000145 [regulation of cell motility]
GO:2000249 [regulation of actin cytoskeleton reorganization]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2000772 [regulation of cellular senescence]
GO:2000773 [negative regulation of cellular senescence]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
1149 aa
125 kDa
No 0
ABL1-003
ENSP00000376971
ENST00000393293
R4GRW0 [Direct mapping]
Tyrosine-protein kinase ABL1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Cancer-related genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0048008 [platelet-derived growth factor receptor signaling pathway]
Show all
64 aa
6.9 kDa
No 0

Contact

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The Project

  • INTRODUCTION
  • ORGANIZATION
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  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.