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Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) after the treatment of U-2 OS cells with brefeldin A (5 ug/ml) for 30 minutes to disrupt the ER to Golgi transport; GOLGA2 localizes together with proteins associated with the Golgi-matrix (PMID: 8557739). DEPDC5 is a Golgi-matrix protein, as it co-localizes with the Golgi-matrix marker GOLGA2 after the treatment with BFA.
Co-localization with the cis-Golgi marker GM130/GOLGA2 (RRID:AB_398141) for a refined protein localization within the Golgi apparatus in U-2 OS cells. DEPDC5 localizes to the Golgi apparatus, and is only detected in the cis-Golgi compartment.
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
O75140 [Direct mapping] DEP domain-containing protein 5
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THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O75140 [Direct mapping] DEP domain-containing protein 5
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O75140 [Direct mapping] DEP domain-containing protein 5
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O75140 [Direct mapping] DEP domain-containing protein 5
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)