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Several hepatocellular carcinomas, prostate and thyroid cancers displayed a few cases with moderate cytoplasmic and occasional membranous immunoreactivity. Most remaining cancer tissues were negative.
GENE INFORMATION
Gene name
DEPDC5 (HGNC Symbol)
Synonyms
DEP.5, KIAA0645
Description
DEP domain containing 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
O75140 [Direct mapping] DEP domain-containing protein 5
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O75140 [Direct mapping] DEP domain-containing protein 5
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O75140 [Direct mapping] DEP domain-containing protein 5
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
O75140 [Direct mapping] DEP domain-containing protein 5
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)