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Gene name

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Chromosome

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In atlas

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Reliability

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Method

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Cancer

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Tissue

Detectable

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Detectable

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VAMP8
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

VAMP8

Gene description

Vesicle-associated membrane protein 8

Protein class

Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

Intracellular,Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Supported based on 3 antibodies.
HPA006882 , CAB037132 , CAB037147
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Bone marrow

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

VAMP8 (HGNC Symbol)

Synonyms

EDB

Description

Vesicle-associated membrane protein 8 (HGNC Symbol)

Entrez gene summary

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

Chromosome

2

Cytoband

p11.2

Chromosome location (bp)

85561562 - 85582031

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000118640 (version 83.38)

Entrez gene

8673

UniProt

Q9BV40 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BV40

Antibodypedia

VAMP8 antibodies

PROTEIN BROWSER

VAMP8-001
VAMP8-002
VAMP8-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

VAMP8-001
ENSP00000263864
ENST00000263864
Q9BV40 [Direct mapping]
Vesicle-associated membrane protein 8
Show all
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0006906 [vesicle fusion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
GO:0019869 [chloride channel inhibitor activity]
GO:0030667 [secretory granule membrane]
GO:0031201 [SNARE complex]
GO:0031901 [early endosome membrane]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0035577 [azurophil granule membrane]
GO:0046718 [viral entry into host cell]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070254 [mucus secretion]
GO:0097352 [autophagosome maturation]
GO:0098594 [mucin granule]
GO:1903076 [regulation of protein localization to plasma membrane]
GO:1903531 [negative regulation of secretion by cell]
GO:1903595 [positive regulation of histamine secretion by mast cell]
Show all
100 aa
11.4 kDa
No 1
VAMP8-002
ENSP00000407984
ENST00000432071
C9JXZ5 [Direct mapping]
Vesicle-associated membrane protein 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
74 aa
8.6 kDa
No 1
VAMP8-003
ENSP00000387094
ENST00000409760
B8ZZT4 [Direct mapping]
Vesicle-associated membrane protein 8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000149 [SNARE binding]
GO:0005484 [SNAP receptor activity]
GO:0006906 [vesicle fusion]
GO:0016021 [integral component of membrane]
GO:0016192 [vesicle-mediated transport]
Show all
99 aa
11.2 kDa
No 0

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