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Most of endometrial cancers displayed moderate to strong membranous staining. Few cases of seminomas and urothelial cancers displayed weak to moderate cytoplasmic positivity. A case of liver, renal and pancreatic cancer displayed weak nuclear positivity. Rest of cancer tissues were negative.
GENE INFORMATION
Gene name
NPHP4 (HGNC Symbol)
Synonyms
KIAA0673, POC10, SLSN4
Description
Nephronophthisis 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]