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FPGS

GENERAL INFORMATION

Gene name

 FPGS

Gene description

 Folylpolyglutamate synthase

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, highly abundant in smooth muscles.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA050488
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA050488

GENE INFORMATION

Gene name

 FPGS

Synonyms

Description

 Folylpolyglutamate synthase (HGNC Symbol)

Entrez gene summary

 This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Chromosome

 9

Cytoband

 q34.11

Chromosome location (bp)

 127794597 - 127814327

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000136877 (version 83.38)

Entrez gene

 2356

UniProt

 Q05932 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05932

Antibodypedia

 FPGS antibodies

PROTEIN BROWSER
FPGS-001
FPGS-011
FPGS-012
FPGS-017
FPGS-020
FPGS-201
FPGS-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FPGS-001
ENSP00000406328
ENST00000423577
Q5JU21 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
 194 aa
21.6 kDa 		No 0
FPGS-011
ENSP00000362344
ENST00000373247
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007420 [brain development]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0031100 [organ regeneration]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
 587 aa
64.6 kDa 		Yes 0
FPGS-012
ENSP00000362322
ENST00000373225
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
 537 aa
59.2 kDa 		No 0
FPGS-017
ENSP00000362325
ENST00000373228
Q5JU23 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
 375 aa
40.9 kDa 		Yes 0
FPGS-020
ENSP00000400007
ENST00000431857
Q5JU20 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
 265 aa
29.2 kDa 		No 0
FPGS-201
ENSP00000377309
ENST00000393706
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
 561 aa
61.6 kDa 		Yes 0
FPGS-202
ENSP00000486766
ENST00000630236
Q5JU23 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
 375 aa
40.9 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.