We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Fields »
 

Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
ABOUT
HELP
BLOG
  • THE HUMAN PROTEOME
  • THE HUMAN TISSUES
  • THE HUMAN CELL
  • HUMAN PATHOLOGY
  • PROTEIN CLASSES
  • PROTEIN EVIDENCE
    • NEWS
    • BLOG
    • EVENTS
    • PRESS ROOM
    • LEARN
    • DICTIONARY
    • METHODS
    • CELL LINES
  • THE PROJECT
  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • PUBLICATION DATA
  • ANTIBODY SUBMISSION
  • ANTIBODY AVAILABILITY
  • LINKS
  • CONTACT
  • TECHNICAL DATA
  • ANTIBODY VALIDATION
  • ASSAYS & ANNOTATION
  • DISCLAIMER
  • DOWNLOADABLE DATA
  • HELP & FAQ
  • LICENCE & CITATION
  • PRIVACY STATEMENT
  • RELEASE HISTORY
FPGS
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

FPGS

Gene description

Folylpolyglutamate synthase

Protein class

Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, highly abundant in smooth muscles.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA050488
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA050488

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Duct carcinomas of breast, squamous cell carcinomas of cervix and occasional cases of cholangiocarcinomas showed moderate to strong membranous and cytoplasmic staining. Few cases of ovarian, pancreas and urothelial cancers displayed moderate positivity while papillary adenocarcinomas of thyroid showed moderate cytoplasmic staining. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

FPGS

Synonyms

Description

Folylpolyglutamate synthase (HGNC Symbol)

Entrez gene summary

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

Chromosome

9

Cytoband

q34.11

Chromosome location (bp)

127794597 - 127814327

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000136877 (version 83.38)

Entrez gene

2356

UniProt

Q05932 (UniProt - Evidence at protein level)

neXtProt

NX_Q05932

Antibodypedia

FPGS antibodies

PROTEIN BROWSER

FPGS-001
FPGS-011
FPGS-012
FPGS-017
FPGS-020
FPGS-201
FPGS-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FPGS-001
ENSP00000406328
ENST00000423577
Q5JU21 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
194 aa
21.6 kDa
No 0
FPGS-011
ENSP00000362344
ENST00000373247
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001889 [liver development]
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0007420 [brain development]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0031100 [organ regeneration]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
587 aa
64.6 kDa
Yes 0
FPGS-012
ENSP00000362322
ENST00000373225
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
537 aa
59.2 kDa
No 0
FPGS-017
ENSP00000362325
ENST00000373228
Q5JU23 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
375 aa
40.9 kDa
Yes 0
FPGS-020
ENSP00000400007
ENST00000431857
Q5JU20 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
265 aa
29.2 kDa
No 0
FPGS-201
ENSP00000377309
ENST00000393706
Q05932 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0005829 [cytosol]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006730 [one-carbon metabolic process]
GO:0006760 [folic acid-containing compound metabolic process]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0008283 [cell proliferation]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0016874 [ligase activity]
GO:0044281 [small molecule metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
561 aa
61.6 kDa
Yes 0
FPGS-202
ENSP00000486766
ENST00000630236
Q5JU23 [Direct mapping]
Folylpolyglutamate synthase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004326 [tetrahydrofolylpolyglutamate synthase activity]
GO:0005524 [ATP binding]
GO:0009058 [biosynthetic process]
GO:0009396 [folic acid-containing compound biosynthetic process]
GO:0046901 [tetrahydrofolylpolyglutamate biosynthetic process]
Show all
375 aa
40.9 kDa
Yes 0

Contact

  • BLOG
  • PRESS ROOM
  • contact@proteinatlas.org

The Project

  • INTRODUCTION
  • ORGANIZATION
  • PUBLICATIONS
  • DOWNLOADABLE DATA

The Human Protein Atlas

  • ANTIBODY AVAILABILITY
  • LICENCE & CITATION
  • HELP & FAQ
The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.