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MAT2A

GENERAL INFORMATION

Gene name

 MAT2A

Gene description

 Methionine adenosyltransferase II, alpha

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA043028 , CAB009968
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), melanoma (unfavourable), liver cancer (unfavourable) and lung cancer (favourable).
Endometrial cancer p<0.001
Melanoma p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Cervical cancer

STAINING SUMMARY
HPA043028
CAB009968

GENE INFORMATION

Gene name

 MAT2A (HGNC Symbol)

Synonyms

 MATA2, MATII, SAMS2

Description

 Methionine adenosyltransferase II, alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

Chromosome

 2

Cytoband

 p11.2

Chromosome location (bp)

 85539165 - 85545280

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168906 (version 83.38)

Entrez gene

 4144

UniProt

 P31153 (UniProt - Evidence at protein level)

neXtProt

 NX_P31153

Antibodypedia

 MAT2A antibodies

PROTEIN BROWSER
MAT2A-001
MAT2A-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAT2A-001
ENSP00000303147
ENST00000306434
P31153 [Direct mapping]
S-adenosylmethionine synthase isoform type-2
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004478 [methionine adenosyltransferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006556 [S-adenosylmethionine biosynthetic process]
GO:0006730 [one-carbon metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048269 [methionine adenosyltransferase complex]
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 395 aa
43.7 kDa 		No 0
MAT2A-007
ENSP00000386353
ENST00000409017
P31153 [Direct mapping]
S-adenosylmethionine synthase isoform type-2
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004478 [methionine adenosyltransferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006556 [S-adenosylmethionine biosynthetic process]
GO:0006730 [one-carbon metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0032259 [methylation]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0048269 [methionine adenosyltransferase complex]
Show all
 299 aa
33 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.