Expression of C3 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	C3
Gene descriptionⁱ Gene description according to HGNC.	Complement component 3
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (BJ hTERT+, EFO-21, Hep G2, SiHa)
HPA (normal tissue):	Expressed in all

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Distinct positivity in plasma.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 3 antibodies. HPA003563 , HPA020432 , CAB004209
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (unfavourable) and liver cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Expressed in all

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

HPA003563	HPA020432	CAB004209

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	C3 (HGNC Symbol)
Synonyms	ARMD9, C3a, C3b, CPAMD1
Description	Complement component 3 (HGNC Symbol)
Entrez gene summary	Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	6677704 - 6730562
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125730 (version 83.38)
Entrez gene	718
UniProt	P01024 (UniProt - Evidence at protein level)
neXtProt	NX_P01024
Antibodypedia	C3 antibodies

PROTEIN BROWSERⁱ

C3-001	C3-003	C3-014	C3-015	C3-018

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C3-001 ENSP00000245907 ENST00000245907	P01024 [Direct mapping] Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha' chain Complement C3c alpha' chain fragment 1 Complement C3dg fragment Complement C3g fragment Complement C3d fragment Complement C3f fragment Complement C3c alpha' chain fragment 2 V9HWA9 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 62p Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001798 [positive regulation of type IIa hypersensitivity] GO:0001934 [positive regulation of protein phosphorylation] GO:0001970 [positive regulation of activation of membrane attack complex] GO:0002507 [tolerance induction] GO:0004866 [endopeptidase inhibitor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006631 [fatty acid metabolic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0006956 [complement activation] GO:0006957 [complement activation, alternative pathway] GO:0006958 [complement activation, classical pathway] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007596 [blood coagulation] GO:0008289 [lipid binding] GO:0010575 [positive regulation of vascular endothelial growth factor production] GO:0010828 [positive regulation of glucose transport] GO:0010866 [regulation of triglyceride biosynthetic process] GO:0010884 [positive regulation of lipid storage] GO:0010951 [negative regulation of endopeptidase activity] GO:0030449 [regulation of complement activation] GO:0031715 [C5L2 anaphylatoxin chemotactic receptor binding] GO:0032026 [response to magnesium ion] GO:0032355 [response to estradiol] GO:0032570 [response to progesterone] GO:0043627 [response to estrogen] GO:0045087 [innate immune response] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0045766 [positive regulation of angiogenesis] GO:0048037 [cofactor binding] GO:0048639 [positive regulation of developmental growth] GO:0050766 [positive regulation of phagocytosis] GO:0050776 [regulation of immune response] GO:0051384 [response to glucocorticoid] GO:0070062 [extracellular exosome] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:0072562 [blood microparticle] GO:2000427 [positive regulation of apoptotic cell clearance] Show all	1663 aa 187.1 kDa	Yes	0
C3-003 ENSP00000472044 ENST00000600744	M0R1Q1 [Direct mapping] Complement C3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.2 kDa	No	0
C3-014 ENSP00000469482 ENST00000602229	M0QXZ3 [Direct mapping] Complement C3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	100 aa 11.6 kDa	No	0
C3-015 ENSP00000471384 ENST00000601008	M0R0Q9 [Direct mapping] Complement C3 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] Show all	101 aa 11.2 kDa	No	0
C3-018 ENSP00000469744 ENST00000596548	M0QYC8 [Direct mapping] Complement C3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005576 [extracellular region] Show all	192 aa 21.7 kDa	No	0