Cell atlas - PDS5A - The Human Protein Atlas

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PDS5A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS siRNA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	PDS5A
Gene description	PDS5 cohesin associated factor A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
siRNA	The location(s) are Validated based on siRNA mediated gene silencing.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA036661 , HPA036662
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ASSAYS

RNA expression

Human cells

siRNA

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm.

Main location

Nucleoplasm (validated)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA036661	A-431	Nucleoplasm
HPA036661	U-2 OS	Nucleoplasm
HPA036661	U-251 MG	Nucleoplasm
HPA036662	A-431	Nucleoplasm
HPA036662	A-431	Plasma membrane
HPA036662	U-2 OS	Nucleoplasm
HPA036662	U-2 OS	Plasma membrane
HPA036662	U-251 MG	Nucleoplasm

siRNA VALIDATION

Antibody

HPA036661

siRNA validation

Validated: Significant downregulation > 25% by both siRNA:s.

Analysis performed in

Nuclear region of segmented cells in 10x-images

siRNA 1

siRNA 2

RFI

23%

p-value

< 0.01


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Sample	Cell line
HPA036661	siRNA 1	U-2 OS
HPA036661	siRNA 2	U-2 OS
HPA036661	scrambled	U-2 OS

GENE INFORMATION
Gene name	PDS5A (HGNC Symbol)
Synonyms	KIAA0648, PIG54, SCC-112
Description	PDS5 cohesin associated factor A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Chromosome	4
Cytoband	p14
Chromosome location (bp)	39822863 - 39977956
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121892 (version 83.38)
Entrez gene	23244
UniProt	Q29RF7 (UniProt - Evidence at protein level)
neXtProt	NX_Q29RF7
Antibodypedia	PDS5A antibodies

PROTEIN BROWSER

PDS5A-001	PDS5A-003	PDS5A-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDS5A-001 ENSP00000303427 ENST00000303538	Q29RF7 [Direct mapping] Sister chromatid cohesion protein PDS5 homolog A G1UI16 [Target identity:100%; Query identity:100%] SCC-112 protein, isoform CRA_b; Sister chromatid cohesion protein PDS5 homolog A Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000785 [chromatin] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007064 [mitotic sister chromatid cohesion] GO:0008156 [negative regulation of DNA replication] GO:0051301 [cell division] Show all	1337 aa 150.8 kDa	No	0
PDS5A-003 ENSP00000426749 ENST00000503396	Q29RF7 [Direct mapping] Sister chromatid cohesion protein PDS5 homolog A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000785 [chromatin] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0007064 [mitotic sister chromatid cohesion] GO:0008156 [negative regulation of DNA replication] GO:0051301 [cell division] Show all	600 aa 69 kDa	No	0
PDS5A-006 ENSP00000424531 ENST00000513798	H0Y9L9 [Direct mapping] Sister chromatid cohesion protein PDS5 homolog A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		165 aa 19.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.