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Citing the Human Protein Atlas To cite us, please use:
The Human Protein Atlas
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Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Tissue-based map of the human proteome.
Science 2015 347(6220):1260419.
PubMed: 25613900 DOI: 10.1126/science.1260419
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Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, Zwahlen M, Kampf C, Wester K, Hober S, Wernerus H, Björling L, Ponten F.
Towards a knowledge-based Human Protein Atlas.
Nat Biotechnol. 2010 28(12):1248-50.
PubMed: 21139605 DOI: 10.1038/nbt1210-1248
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The Cell Atlas
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Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
PubMed: 28495876 DOI: 10.1126/science.aal3321 Free access:
Abstract,
Full text,
Reprint
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The Pathology Atlas
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Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
PubMed: 28818916 DOI: 10.1126/science.aan2507
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The original Human Protein Atlas publication
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Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200
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Publications
421 |
Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
PubMed: 28818916 DOI: 10.1126/science.aan2507
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420 |
Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
PubMed: 28495876 DOI: 10.1126/science.aal3321
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419 |
Kannan P, Schain M, Kretzschmar WW, Weidner L, Mitsios N, Gulyás B, Blom H, Gottesman MM, Innis RB, Hall MD, Mulder J.
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.
J Cereb Blood Flow Metab. 2016 Epub ahead of print
PubMed: 27488911 DOI: 10.1177/0271678X16660984
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418 |
Musunuri S, Khoonsari PE, Mikus M, Wetterhall M, Häggmark-Mänberg A, Lannfelt L, Erlandsson A, Bergquist J, Ingelsson M, Shevchenko G, Nilsson P, Kultima K.
Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain.
J Alzheimers Dis. 2016 54(4):1671-1686.
PubMed: 27636840 DOI: 10.3233/JAD-160271
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417 |
Thelin EP, Just D, Frostell A, Häggmark-Månberg A, Risling M, Svensson M, Nilsson P, Bellander BM.
Protein profiling in serum after traumatic brain injury in rats reveals potential injury markers.
Behav Brain Res. 2016 Epub ahead of print
PubMed: 27591967 DOI: 10.1016/j.bbr.2016.08.058
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416 |
Ayoglu B, Schwenk JM, Nilsson P.
Antigen arrays for profiling autoantibody repertoires.
Bioanalysis. 2016 8(10):1105-26.
PubMed: 27097564 DOI: 10.4155/bio.16.31
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415 |
Schrötter A, Park YM, Marcus K, Martins-de-Souza D, Nilsson P, Magraoui FE, Meyer HE, Grinberg LT.
Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada.
Proteomics. 2016 16(7):1047-50.
PubMed: 26872682 DOI: 10.1002/pmic.201600047
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414 |
Khoonsari PE, Häggmark A, Lönnberg M, Mikus M, Kilander L, Lannfelt L, Bergquist J, Ingelsson M, Nilsson P, Kultima K, Shevchenko G.
Analysis of the Cerebrospinal Fluid Proteome in Alzheimer's Disease.
PLoS One. 2016 11(3):e0150672.
PubMed: 26950848 DOI: 10.1371/journal.pone.0150672
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413 |
Mardinoglu A, Boren J, Smith U.
Confounding Effects of Metformin on the Human Gut Microbiome in Type 2 Diabetes.
Cell Metab. 2016 23(1):10-2.
PubMed: 26771114 DOI: 10.1016/j.cmet.2015.12.012
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412 |
Björnson E, Borén J, Mardinoglu A.
Personalized Cardiovascular Disease Prediction and Treatment-A Review of Existing Strategies and Novel Systems Medicine Tools.
Front Physiol. 2016 7():2.
PubMed: 26858650 DOI: 10.3389/fphys.2016.00002
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411 |
Elsemman IE, Mardinoglu A, Shoaie S, Soliman TH, Nielsen J.
Systems biology analysis of hepatitis C virus infection reveals the role of copy number increases in regions of chromosome 1q in hepatocellular carcinoma metabolism.
Mol Biosyst. 2016 12(5):1496-506.
PubMed: 27040643 DOI: 10.1039/c5mb00827a
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410 |
Lee S, Mardinoglu A, Zhang C, Lee D, Nielsen J.
Dysregulated signaling hubs of liver lipid metabolism reveal hepatocellular carcinoma pathogenesis.
Nucleic Acids Res. 2016 44(12):5529-39.
PubMed: 27216817 DOI: 10.1093/nar/gkw462
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409 |
Zhang C, Lee S, Mardinoglu A, Hua Q.
Investigating the Combinatory Effects of Biological Networks on Gene Co-expression.
Front Physiol. 2016 7():160.
PubMed: 27445830 DOI: 10.3389/fphys.2016.00160
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408 |
Chaudhari A, Håversen L, Mobini R, Andersson L, Ståhlman M, Lu E, Rutberg M, Fogelstrand P, Ekroos K, Mardinoglu A, Levin M, Perkins R, Borén J.
ARAP2 promotes GLUT1-mediated basal glucose uptake through regulation of sphingolipid metabolism.
Biochim Biophys Acta. 2016 1861(11):1643-1651.
PubMed: 27476102 DOI: 10.1016/j.bbalip.2016.07.009
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407 |
Heinonen S, Muniandy M, Buzkova J, Mardinoglu A, Rodríguez A, Frühbeck G, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH.
Mitochondria-related transcriptional signature is downregulated in adipocytes in obesity: a study of young healthy MZ twins.
Diabetologia. 2016 Epub ahead of print
PubMed: 27734103 DOI: 10.1007/s00125-016-4121-2
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406 |
Larsson AH, Lehn S, Wangefjord S, Karnevi E, Kuteeva E, Sundström M, Nodin B, Uhlén M, Eberhard J, Birgisson H, Jirström K.
Significant association and synergistic adverse prognostic effect of podocalyxin-like protein and epidermal growth factor receptor expression in colorectal cancer.
J Transl Med. 2016 14(1):128.
PubMed: 27160084 DOI: 10.1186/s12967-016-0882-0
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405 |
Lee S, Zhang C, Kilicarslan M, Piening BD, Bjornson E, Hallström BM, Groen AK, Ferrannini E, Laakso M, Snyder M, Blüher M, Uhlen M, Nielsen J, Smith U, Serlie MJ, Boren J, Mardinoglu A.
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance.
Cell Metab. 2016 24(1):172-84.
PubMed: 27345421 DOI: 10.1016/j.cmet.2016.05.026
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404 |
Mardinoglu A, Uhlén M.
Liver: Phenotypic and genetic variance: a systems approach to the liver.
Nat Rev Gastroenterol Hepatol. 2016 13(8):439-40.
PubMed: 27329803 DOI: 10.1038/nrgastro.2016.93
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403 |
Mattsson JS, Brunnström H, Jabs V, Edlund K, Jirström K, Mindus S, la Fleur L, Pontén F, Karlsson MG, Karlsson C, Koyi H, Brandén E, Botling J, Helenius G, Micke P, Svensson MA.
Inconsistent results in the analysis of ALK rearrangements in non-small cell lung cancer.
BMC Cancer. 2016 16():603.
PubMed: 27495736 DOI: 10.1186/s12885-016-2646-x
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402 |
Delforoush M, Berglund M, Edqvist PH, Sundström C, Gullbo J, Enblad G.
Expression of possible targets for new proteasome inhibitors in diffuse large B-cell lymphoma.
Eur J Haematol. 2016 Epub ahead of print
PubMed: 27301795 DOI: 10.1111/ejh.12784
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401 |
Boije H, Shirazi Fard S, Edqvist PH, Hallböök F.
Horizontal Cells, the Odd Ones Out in the Retina, Give Insights into Development and Disease.
Front Neuroanat. 2016 10():77.
PubMed: 27486389 DOI: 10.3389/fnana.2016.00077
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400 |
Ståhl PL, Salmén F, Vickovic S, Lundmark A, Navarro JF, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M, Mollbrink A, Linnarsson S, Codeluppi S, Borg Å, Pontén F, Costea PI, Sahlén P, Mulder J, Bergmann O, Lundeberg J, Frisén J.
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.
Science. 2016 353(6294):78-82.
PubMed: 27365449 DOI: 10.1126/science.aaf2403
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399 |
Wallerius M, Wallmann T, Bartish M, Östling J, Mezheyeuski A, Tobin NP, Nygren E, Pangigadde P, Pellegrini P, Squadrito ML, Pontén F, Hartman J, Bergh J, De Milito A, De Palma M, Östman A, Andersson J, Rolny C.
Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.
Cancer Res. 2016 76(11):3166-78.
PubMed: 27197153 DOI: 10.1158/0008-5472.CAN-15-2596
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398 |
Mezheyeuski A, Lindh MB, Guren TK, Dragomir A, Pfeiffer P, Kure EH, Ikdahl T, Skovlund E, Corvigno S, Strell C, Pietras K, Ponten F, Mulder J, Qvortrup C, Portyanko A, Tveit KM, Glimelius B, Sorbye H, Östman A.
Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer.
Oncotarget. 2016 Epub ahead of print
PubMed: 27248825 DOI: 10.18632/oncotarget.9632
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397 |
Zetterling M, Roodakker KR, Berntsson SG, Edqvist PH, Latini F, Landtblom AM, Pontén F, Alafuzoff I, Larsson EM, Smits A.
Extension of diffuse low-grade gliomas beyond radiological borders as shown by the coregistration of histopathological and magnetic resonance imaging data.
J Neurosurg. 2016 ():1-12.
PubMed: 26918468 DOI: 10.3171/2015.10.JNS15583
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396 |
Manojlovic-Gacic E, Skender-Gazibara M, Popovic V, Soldatovic I, Boricic N, Raicevic S, Pekic S, Doknic M, Miljic D, Alafuzoff I, Pontén F, Casar-Borota O.
Oncogene-Induced Senescence in Pituitary Adenomas--an Immunohistochemical Study.
Endocr Pathol. 2016 27(1):1-11.
PubMed: 26573928 DOI: 10.1007/s12022-015-9405-4
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395 |
Landegren N, Sharon D, Freyhult E, Hallgren Å, Eriksson D, Edqvist PH, Bensing S, Wahlberg J, Nelson LM, Gustafsson J, Husebye ES, Anderson MS, Snyder M, Kämpe O.
Proteome-wide survey of the autoimmune target repertoire in autoimmune polyendocrine syndrome type 1.
Sci Rep. 2016 6():20104.
PubMed: 26830021 DOI: 10.1038/srep20104
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394 |
Hellström-Lindahl E, Danielsson A, Ponten F, Czernichow P, Korsgren O, Johansson L, Eriksson O.
GPR44 is a pancreatic protein restricted to the human beta cell.
Acta Diabetol. 2016 53(3):413-21.
PubMed: 26467464 DOI: 10.1007/s00592-015-0811-3
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393 |
Fredrik Edfors, Frida Danielsson, Björn M Hallström, Lukas Käll, Emma Lundberg, Fredrik Ponten, Björn Forsström and Mathias Uhlén
Gene-specific correlation of RNA and protein levels in human cells and tissues
Molecular Systems Biology 2016 883
DOI: 10.15252/msb.20167144
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392 |
Lindskog C, Asplund A, Catrina A, Nielsen S, Rützler M.
A Systematic Characterization of Aquaporin-9 Expression in Human Normal and Pathological Tissues.
J Histochem Cytochem. 2016 64(5):287-300.
PubMed: 27026296 DOI: 10.1369/0022155416641028
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391 |
Hamsten C, Häggmark A, Grundström J, Mikus M, Lindskog C, Konradsen JR, Eklund A, Pershagen G, Wickman M, Grunewald J, Melén E, Hedlin G, Nilsson P, van Hage M.
Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma.
Allergy. 2016 71(9):1357-61.
PubMed: 27145233 DOI: 10.1111/all.12927
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390 |
Lindskog C.
The Human Protein Atlas - an important resource for basic and clinical research.
Expert Rev Proteomics. 2016 13(7):627-9.
PubMed: 27276068 DOI: 10.1080/14789450.2016.1199280
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Vandenbrouck Y, Lane L, Carapito C, Duek P, Rondel K, Bruley C, Macron C, Gonzalez de Peredo A, Couté Y, Chaoui K, Com E, Gateau A, Hesse AM, Marcellin M, Méar L, Mouton-Barbosa E, Robin T, Burlet-Schiltz O, Cianferani S, Ferro M, Fréour T, Lindskog C, Garin J, Pineau C.
Looking for Missing Proteins in the Proteome of Human Spermatozoa: An Update.
J Proteome Res. 2016 Epub ahead of print
PubMed: 27444420 DOI: 10.1021/acs.jproteome.6b00400
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388 |
Volk AL, Hu FJ, Berglund MM, Nordling E, Strömberg P, Uhlen M, Rockberg J.
Stratification of responders towards eculizumab using a structural epitope mapping strategy.
Sci Rep. 2016 6():31365.
PubMed: 27509843 DOI: 10.1038/srep31365
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387 |
Uhlén M, Hallström BM, Lindskog C, Mardinoglu A, Pontén F, Nielsen J.
Transcriptomics resources of human tissues and organs.
Mol Syst Biol. 2016 12(4):862.
PubMed: 27044256
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386 |
Pozniak Y, Balint-Lahat N, Rudolph JD, Lindskog C, Katzir R, Avivi C, Pontén F, Ruppin E, Barshack I, Geiger T.
System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis.
Cell Syst. 2016 2(3):172-84.
PubMed: 27135363 DOI: 10.1016/j.cels.2016.02.001
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385 |
Fukuhara M, Agnarsdóttir M, Edqvist PH, Coter A, Ponten F.
SATB2 is expressed in Merkel cell carcinoma.
Arch Dermatol Res. 2016 308(6):449-54.
PubMed: 27262585 DOI: 10.1007/s00403-016-1655-6
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384 |
Lal S, Nguyen L, Tezone R, Ponten F, Odeberg J, Li A, Dos Remedios C.
Tissue microarray profiling in human heart failure.
Proteomics. 2016 16(17):2319-26.
PubMed: 27364902 DOI: 10.1002/pmic.201600135
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383 |
Fredholm H, Magnusson K, Lindström LS, Garmo H, Fält SE, Lindman H, Bergh J, Holmberg L, Pontén F, Frisell J, Fredriksson I.
Long-term outcome in young women with breast cancer: a population-based study.
Breast Cancer Res Treat. 2016 160(1):131-143.
PubMed: 27624330 DOI: 10.1007/s10549-016-3983-9
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382 |
Roodakker KR, Elsir T, Edqvist PD, Hägerstrand D, Carlson J, Lysiak M, Henriksson R, Pontén F, Rosell J, Söderkvist P, Stupp R, Tchougounova E, Nistér M, Malmström A, Smits A.
PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status.
Oncotarget. 2016 Epub ahead of print
PubMed: 27626492 DOI: 10.18632/oncotarget.11957
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381 |
Butler LM, Hallström BM, Fagerberg L, Pontén F, Uhlén M, Renné T, Odeberg J.
Analysis of Body-wide Unfractionated Tissue Data to Identify a Core Human Endothelial Transcriptome.
Cell Syst. 2016 3(3):287-301.e3.
PubMed: 27641958 DOI: 10.1016/j.cels.2016.08.001
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380 |
Eriksson O, Asplund A, Hegde G, Edqvist PH, Navani S, Pontén F, Siegbahn A.
A stromal cell population in the large intestine identified by tissue factor expression that is lost during colorectal cancer progression.
Thromb Haemost. 2016 116(6):.
PubMed: 27656710 DOI: 10.1160/TH16-04-0267
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379 |
Djureinovic D, Hallström BM, Horie M, Mattsson JS, La Fleur L, Fagerberg L, Brunnström H, Lindskog C, Madjar K, Rahnenführer J, Ekman S, Ståhle E, Koyi H, Brandén E, Edlund K, Hengstler JG, Lambe M, Saito A, Botling J, Pontén F, Uhlén M, Micke P.
Profiling cancer testis antigens in non-small-cell lung cancer.
JCI Insight. 2016 1(10):e86837.
PubMed: 27699219 DOI: 10.1172/jci.insight.86837
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378 |
Pin E, Henjes F, Hong MG, Wiklund F, Magnusson P, Bjartell A, Uhlén M, Nilsson P, Schwenk JM.
Identification Of A Novel Autoimmune Peptide Epitope Of Prostein In Prostate Cancer.
J Proteome Res. 2016 Epub ahead of print
PubMed: 27700103 DOI: 10.1021/acs.jproteome.6b00620
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Remnestål J, Just D, Mitsios N, Fredolini C, Mulder J, Schwenk JM, Uhlén M, Kultima K, Ingelsson M, Kilander L, Lannfelt L, Svenningsson P, Nellgård B, Zetterberg H, Blennow K, Nilsson P, Häggmark-Månberg A.
CSF profiling of the human brain enriched proteome reveals associations of neuromodulin and neurogranin to Alzheimer's disease.
Proteomics Clin Appl. 2016 Epub ahead of print
PubMed: 27604409 DOI: 10.1002/prca.201500150
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Hong MG, Lee W, Nilsson P, Pawitan Y, Schwenk JM.
Multidimensional Normalization to Minimize Plate Effects of Suspension Bead Array Data.
J Proteome Res. 2016 15(10):3473-3480.
PubMed: 27570895 DOI: 10.1021/acs.jproteome.5b01131
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Hamsten C, Wiklundh E, Grönlund H, Schwenk JM, Uhlén M, Eklund A, Nilsson P, Grunewald J, Häggmark-Månberg A.
Elevated levels of FN1 and CCL2 in bronchoalveolar lavage fluid from sarcoidosis patients.
Respir Res. 2016 17(1):69.
PubMed: 27259755 DOI: 10.1186/s12931-016-0381-0
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Mikus M, Drobin K, Gry M, Bachmann J, Lindberg J, Yimer G, Aklillu E, Makonnen E, Aderaye G, Roach J, Fier I, Kampf C, Göpfert J, Perazzo H, Poynard T, Stephens C, Andrade RJ, Lucena MI, Arber N, Uhlén M, Watkins PB, Schwenk JM, Nilsson P, Schuppe-Koistinen I.
Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.
Liver Int. 2016 Epub ahead of print
PubMed: 27224670 DOI: 10.1111/liv.13174
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Häggmark-Månberg A, Zandian A, Forsström B, Khademi M, Lima Bomfim I, Hellström C, Arnheim-Dahlström L, Hallböök T, Darin N, Lundberg IE, Uhlén M, Partinen M, Schwenk JM, Olsson T, Nilsson P.
Autoantibody targets in vaccine-associated narcolepsy.
Autoimmunity. 2016 ():1-13.
PubMed: 27206786 DOI: 10.1080/08916934.2016.1183655
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Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T.
Voices of biotech.
Nat Biotechnol. 2016 34(3):270-5.
PubMed: 26963549 DOI: 10.1038/nbt.3502
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Omenn GS, Lane L, Lundberg EK, Beavis RC, Overall CM, Deutsch EW.
Metrics for the Human Proteome Project 2016: Progress on Identifying and Characterizing the Human Proteome, Including Post-Translational Modifications.
J Proteome Res. 2016 Epub ahead of print
PubMed: 27487407 DOI: 10.1021/acs.jproteome.6b00511
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Uhlen M, Bandrowski A, Carr S, Edwards A, Ellenberg J, Lundberg E, Rimm DL, Rodriguez H, Hiltke T, Snyder M, Yamamoto T.
A proposal for validation of antibodies.
Nat Methods. 2016 13(10):823-7.
PubMed: 27595404 DOI: 10.1038/nmeth.3995
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Ayoglu B, Birgersson E, Mezger A, Nilsson M, Uhlén M, Nilsson P, Schwenk JM.
Multiplexed protein profiling by sequential affinity capture.
Proteomics. 2016 Epub ahead of print
PubMed: 26935855 DOI: 10.1002/pmic.201500398
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Ayoglu B, Mitsios N, Kockum I, Khademi M, Zandian A, Sjöberg R, Forsström B, Bredenberg J, Lima Bomfim I, Holmgren E, Grönlund H, Guerreiro-Cacais AO, Abdelmagid N, Uhlén M, Waterboer T, Alfredsson L, Mulder J, Schwenk JM, Olsson T, Nilsson P.
Anoctamin 2 identified as an autoimmune target in multiple sclerosis.
Proc Natl Acad Sci U S A. 2016 113(8):2188-93.
PubMed: 26862169 DOI: 10.1073/pnas.1518553113
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Fredolini C, Byström S, Pin E, Edfors F, Tamburro D, Iglesias MJ, Häggmark A, Hong MG, Uhlen M, Nilsson P, Schwenk JM.
Immunocapture strategies in translational proteomics.
Expert Rev Proteomics. 2016 13(1):83-98.
PubMed: 26558424 DOI: 10.1586/14789450.2016.1111141
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Zhang MD, Barde S, Szodorai E, Josephson A, Mitsios N, Watanabe M, Attems J, Lubec G, Kovács GM, Uhlén M, Mulder J, Harkany T, Hökfelt T.
Comparative anatomical distribution of neuronal calcium-binding protein (NECAB) 1 and -2 in rodent and human spinal cord.
Brain Struct Funct. 2016 Epub ahead of print
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Improved production of a heterologous amylase in Saccharomyces cerevisiae by inverse metabolic engineering.
Appl Environ Microbiol. 2014 80(17):5542-50.
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High expression of RNA-binding motif protein 3 in esophageal and gastric adenocarcinoma correlates with intestinal metaplasia-associated tumours and independently predicts a reduced risk of recurrence and death.
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Affinity Proteomic Profiling of Plasma, Cerebrospinal Fluid, and Brain Tissue within Multiple Sclerosis.
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Defining the human gallbladder proteome by transcriptomics and affinity proteomics.
Proteomics. 2014 Epub ahead of print
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Defining the Human Adipose Tissue Proteome To Reveal Metabolic Alterations in Obesity.
J Proteome Res. 2014 Epub ahead of print
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Libard S, Popova SN, Amini RM, Kärjä V, Pietiläinen T, Hämäläinen KM, Sundström C, Hesselager G, Bergqvist M, Ekman S, Zetterling M, Smits A, Nilsson P, Pfeifer S, de Ståhl TD, Enblad G, Ponten F, Alafuzoff I.
Human Cytomegalovirus Tegument Protein pp65 Is Detected in All Intra- and Extra-Axial Brain Tumours Independent of the Tumour Type or Grade.
PLoS One. 2014 9(9):e108861.
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Characterization of Leukocyte Formin FMNL1 Expression in Human Tissues.
J Histochem Cytochem. 2014 62(6):460-470.
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Sooman L, Freyhult E, Jaiswal A, Navani S, Edqvist PH, Pontén F, Tchougounova E, Smits A, Elsir T, Gullbo J, Lennartsson J, Bergqvist M, Ekman S.
FGF2 as a potential prognostic biomarker for proneural glioma patients.
Acta Oncol. 2014 ():1-10.
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Lindskog C, Fagerberg L, Hallström B, Edlund K, Hellwig B, Rahnenführer J, Kampf C, Uhlén M, Pontén F, Micke P.
The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling.
FASEB J. 2014 Epub ahead of print
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Gremel G, Liew M, Hamzei F, Hardell E, Selling J, Ghaderi M, Stemme S, Pontén F, Carlson JW.
A prognosis based classification of undifferentiated uterine sarcomas: Identification of mitotic index, hormone receptors and YWHAE-FAM22 translocation status as predictors of survival.
Int J Cancer. 2014 Epub ahead of print
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The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer.
Br J Cancer. 2014 111(6):1180-7.
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Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.
Breast Cancer Res. 2014 16(4):R79.
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Ayoglu B, Chaouch A, Lochmüller H, Politano L, Bertini E, Spitali P, Hiller M, Niks EH, Gualandi F, Pontén F, Bushby K, Aartsma-Rus A, Schwartz E, Le Priol Y, Straub V, Uhlén M, Cirak S, 't Hoen PA, Muntoni F, Ferlini A, Schwenk JM, Nilsson P, Al-Khalili Szigyarto C.
Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies.
EMBO Mol Med. 2014 6(7):918-36.
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Analysis of candidate genes for lineage-specific expression changes in humans and primates.
J Proteome Res. 2014 13(8):3596-606.
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Gremel G, Wanders A, Cedernaes J, Fagerberg L, Hallström B, Edlund K, Sjöstedt E, Uhlén M, Pontén F.
The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling.
J Gastroenterol. 2014 Epub ahead of print
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Garbage in, garbage out: a critical evaluation of strategies used for validation of immunohistochemical biomarkers.
Mol Oncol. 2014 8(4):783-98.
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Dragomir A, de Wit M, Johansson C, Uhlen M, Pontén F.
The role of SATB2 as a diagnostic marker for tumors of colorectal origin: Results of a pathology-based clinical prospective study.
Am J Clin Pathol. 2014 141(5):630-8.
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Micke P, Mattsson JS, Edlund K, Lohr M, Jirström K, Berglund A, Botling J, Rahnenfuehrer J, Marincevic M, Pontén F, Ekman S, Hengstler J, Wöll S, Sahin U, Türeci O.
Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer.
Int J Cancer. 2014 135(9):2206-14.
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Kampf C, Mardinoglu A, Fagerberg L, Hallström BM, Edlund K, Lundberg E, Pontén F, Nielsen J, Uhlen M.
The human liver-specific proteome defined by transcriptomics and antibody-based profiling.
FASEB J. 2014 28(7):2901-14.
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Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling.
Mol Syst Biol. 2014 10():721.
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Liem DA, Nsair A, Setty SP, Cadeiras M, Wang D, Maclellan R, Lotz C, Lin AJ, Tabaraki J, Li H, Ge J, Odeberg J, Ponten F, Larson E, Mulder J, Lundberg E, Weiss JN, Uhlen M, Ping P, Deng MC.
Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support.
Circ Heart Fail. 2014 7(2):359-66.
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Cancer Med. 2014 3(3):485-91.
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Djureinovic D, Fagerberg L, Hallström B, Danielsson A, Lindskog C, Uhlén M, Pontén F.
The human testis-specific proteome defined by transcriptomics and antibody-based profiling.
Mol Hum Reprod. 2014 20(6):476-88.
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Howat WJ, Lewis A, Jones P, Kampf C, Pontén F, van der Loos CM, Gray N, Womack C, Warford A.
Antibody validation of immunohistochemistry for biomarker discovery: Recommendations of a consortium of academic and pharmaceutical based histopathology researchers.
Methods. 2014 Epub ahead of print
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Sooman L, Ekman S, Tsakonas G, Jaiswal A, Navani S, Edqvist PH, Pontén F, Bergström S, Johansson M, Wu X, Blomquist E, Bergqvist M, Gullbo J, Lennartsson J.
PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas.
Tumour Biol. 2014 35(5):4479-88.
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Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK.
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.
Nat Commun. 2014 5():3128.
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Hansson J, Hultenby K, Cramnert C, Pontén F, Jansson H, Lindgren D, Axelson H, Johansson ME.
Evidence for a morphologically distinct and functionally robust cell type in the proximal tubules of human kidney.
Hum Pathol. 2014 45(2):382-93.
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Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease.
Nat Commun. 2014 5():3083.
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de Wit M, Kant H, Piersma SR, Pham TV, Mongera S, van Berkel MP, Boven E, Pontén F, Meijer GA, Jimenez CR, Fijneman RJ.
Colorectal cancer candidate biomarkers identified by tissue secretome proteome profiling.
J Proteomics. 2014 99():26-39.
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Hansson SF, Korsgren S, Pontén F, Korsgren O.
Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry?
Diabetologia. 2014 57(3):645-6.
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Gremel G, Bergman J, Djureinovic D, Edqvist PH, Maindad V, Bharambe BM, Khan WA, Navani S, Elebro J, Jirström K, Hellberg D, Uhlén M, Micke P, Pontén F.
A systematic analysis of commonly used antibodies in cancer diagnostics.
Histopathology. 2014 64(2):293-305.
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Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.
Mol Cell Proteomics. 2014 13(2):397-406.
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WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism.
Carcinogenesis. 2014 35(4):784-94.
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Detection of the human endogenous retrovirus ERV3-encoded Env-protein in human tissues using antibody-based proteomics.
J R Soc Med. 2014 107(1):22-9.
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Subtyping of gliomas of various WHO grades by the application of immunohistochemistry.
Histopathology. 2014 64(3):365-79.
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Immunoproteomics using polyclonal antibodies and stable isotope-labeled affinity-purified recombinant proteins.
Mol Cell Proteomics. 2014 13(6):1611-24.
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Investigating the Applicability of Antibodies Generated within the Human Protein Atlas as Capture Agents in Immunoenrichment Coupled to Mass Spectrometry.
J Proteome Res. 2014 Epub ahead of print
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Antibody performance in western blot applications is context-dependent.
Biotechnol J. 2014 9(3):435-45.
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Forsström B, Bisławska Axnas B, Stengele KP, Bühler J, Albert TJ, Richmond TA, Jingxin Hu F, Nilsson P, Hudson EP, Rockberg J, Uhlen M.
Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays.
Mol Cell Proteomics. 2014 Epub ahead of print
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Bachmann J, Burté F, Pramana S, Conte I, Brown BJ, Orimadegun AE, Ajetunmobi WA, Afolabi NK, Akinkunmi F, Omokhodion S, Akinbami FO, Shokunbi WA, Kampf C, Pawitan Y, Uhlén M, Sodeinde O, Schwenk JM, Wahlgren M, Fernandez-Reyes D, Nilsson P.
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria.
PLoS Pathog. 2014 10(4):e1004038.
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Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer.
Br J Cancer. 2013 108(11):2321-8.
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Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro.
PLoS One. 2013 8(7):e70596.
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Integration of cardiac proteome biology and medicine by a specialized knowledgebase.
Circ Res. 2013 113(9):1043-53.
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Gremel G, Grannas K, Sutton LA, Pontén F, Zieba A.
In situ Protein Detection for Companion Diagnostics.
Front Oncol. 2013 3():271.
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Functional stimulation of graft nerves has minor effects on insulin release from transplanted rat pancreatic islets.
Ups J Med Sci. 2013 118(4):209-16.
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Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium.
J Proteome Res. 2013 12(1):135-50.
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Developments in biobanking workflow standardization providing sample integrity and stability.
J Proteomics. 2013 95():38-45.
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Häggmark A, Byström S, Ayoglu B, Qundos U, Uhlén M, Khademi M, Olsson T, Schwenk JM, Nilsson P.
Antibody-based profiling of cerebrospinal fluid within multiple sclerosis.
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Autoantibody profiling in multiple sclerosis using arrays of human protein fragments.
Mol Cell Proteomics. 2013 12(9):2657-72.
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Methods Mol Biol. 2013 1023():137-45.
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Development of a coordinated allo T-cell and auto B-cell response against autosomal PTK2B after allogeneic hematopoietic stem cell transplantation.
Haematologica. 2013 Epub ahead of print
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Profiling post-centrifugation delay of serum and plasma with antibody bead arrays.
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Proteomics. 2013 Epub ahead of print
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Automated classification of immunostaining patterns in breast tissue from the human protein atlas.
J Pathol Inform. 2013 4(Suppl):S14.
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Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival.
Med Oncol. 2013 30(3):638.
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A texture based pattern recognition approach to distinguish melanoma from non-melanoma cells in histopathological tissue microarray sections.
PLoS One. 2013 8(5):e62070.
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Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.
Mol Oncol. 2013 Epub ahead of print
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Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis.
Arterioscler Thromb Vasc Biol. 2013 33(10):2432-43.
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Investigation of Molecular Alterations of AKT-3 in Triple Negative Breast Cancer.
Histopathology. 2013 Epub ahead of print
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Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer.
BMC Cancer. 2013 13():175.
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Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling.
Gastroenterology. 2013 144(5):1001-11.
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Integration of clinical data with a genome-scale metabolic model of the human adipocyte.
Mol Syst Biol. 2013 9():649.
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European H16N3 gull influenza virus attaches to the human respiratory tract and eye.
PLoS One. 2013 8(4):e60757.
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Heart research advances using database search engines, human protein atlas and the sydney heart bank.
Heart Lung Circ. 2013 22(10):819-26.
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Progesterone receptor negativity is an independent risk factor for relapse in patients with early stage endometrioid endometrial adenocarcinoma.
Gynecol Oncol. 2013 130(3):463-9.
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Improving the diagnosis and management of neuroendocrine tumors: utilizing new advances in biomarker and molecular imaging science.
Neuroendocrinology. 2013 98(1):16-30.
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Andrade J, Berglund L, Uhlén M, Odeberg J.
Using Grid technology for computationally intensive applied bioinformatics analyses.
In Silico Biol. 2006 6(6):495-504.
PubMed: 17518760
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18 |
Persson A, Hober S, Uhlén M.
A human protein atlas based on antibody proteomics.
Curr Opin Mol Ther. 2006 8(3):185-90.
PubMed: 16774037
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17 |
Ek S, Andréasson U, Hober S, Kampf C, Pontén F, Uhlén M, Merz H, Borrebaeck CA.
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Mol Cell Proteomics. 2006 5(6):1072-81.
PubMed: 16524965 DOI: 10.1074/mcp.M600077-MCP200
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16 |
Eriksson C, Agaton C, Kånge R, Sundberg M, Nilsson P, Ek B, Uhlén M, Gustafsson M, Hober S.
Microfluidic analysis of antibody specificity in a compact disk format.
J Proteome Res. 2006 5(7):1568-74.
PubMed: 16823963 DOI: 10.1021/pr050447c
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15 |
Haab BB, Paulovich AG, Anderson NL, Clark AM, Downing GJ, Hermjakob H, Labaer J, Uhlen M.
A reagent resource to identify proteins and peptides of interest for the cancer community: a workshop report.
Mol Cell Proteomics. 2006 5(10):1996-2007.
PubMed: 16867976 DOI: 10.1074/mcp.T600020-MCP200
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14 |
Larsson K, Wester K, Nilsson P, Uhlén M, Hober S, Wernérus H.
Multiplexed PrEST immunization for high-throughput affinity proteomics.
J Immunol Methods. 2006 315(1-2):110-20.
PubMed: 16949094 DOI: 10.1016/j.jim.2006.07.014
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13 |
Andersson AC, Strömberg S, Bäckvall H, Kampf C, Uhlen M, Wester K, Pontén F.
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J Histochem Cytochem. 2006 54(12):1413-23.
PubMed: 16957166 DOI: 10.1369/jhc.6A7001.2006
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12 |
Rada-Iglesias A, Wallerman O, Koch C, Ameur A, Enroth S, Clelland G, Wester K, Wilcox S, Dovey OM, Ellis PD, Wraight VL, James K, Andrews R, Langford C, Dhami P, Carter N, Vetrie D, Pontén F, Komorowski J, Dunham I, Wadelius C.
Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.
Hum Mol Genet. 2005 14(22):3435-47.
PubMed: 16221759 DOI: 10.1093/hmg/ddi378
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11 |
Janzi M, Odling J, Pan-Hammarström Q, Sundberg M, Lundeberg J, Uhlén M, Hammarström L, Nilsson P.
Serum microarrays for large scale screening of protein levels.
Mol Cell Proteomics. 2005 4(12):1942-7.
PubMed: 16131484 DOI: 10.1074/mcp.M500213-MCP200
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10 |
Nilsson P, Paavilainen L, Larsson K, Odling J, Sundberg M, Andersson AC, Kampf C, Persson A, Al-Khalili Szigyarto C, Ottosson J, Björling E, Hober S, Wernérus H, Wester K, Pontén F, Uhlen M.
Towards a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling.
Proteomics. 2005 5(17):4327-37.
PubMed: 16237735 DOI: 10.1002/pmic.200500072
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9 |
Hedhammar M, Stenvall M, Lönneborg R, Nord O, Sjölin O, Brismar H, Uhlén M, Ottosson J, Hober S.
A novel flow cytometry-based method for analysis of expression levels in Escherichia coli, giving information about precipitated and soluble protein.
J Biotechnol. 2005 119(2):133-46.
PubMed: 15996784 DOI: 10.1016/j.jbiotec.2005.03.024
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8 |
Stenvall M, Steen J, Uhlén M, Hober S, Ottosson J.
High-throughput solubility assay for purified recombinant protein immunogens.
Biochim Biophys Acta. 2005 1752(1):6-10.
PubMed: 16084133 DOI: 10.1016/j.bbapap.2005.07.002
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7 |
Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200
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6 |
Lindskog M, Rockberg J, Uhlen M, Sterky F.
Selection of protein epitopes for antibody production
Biotechniques 2005 38(5):723-7.
PubMed: 15945371
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5 |
Uhlen M, Ponten F.
Antibody-based proteomics for human tissue profiling.
Mol Cell Proteomics. 2005 4(4):384-93.
PubMed: 15695805 DOI: 10.1074/mcp.R500009-MCP200
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4 |
Kampf C, Andersson A-C, Wester K, Björling E, Uhlen M, Ponten F
Antibody-based tissue profiling as a tool in clinical proteomics
Clin. Proteomics 2004 1(3-4):285-300.
DOI: 10.1385/CP:1:3-4:285
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3 |
Agaton C, Uhlén M, Hober S.
Genome-based proteomics.
Electrophoresis. 2004 25(9):1280-8.
PubMed: 15174050 DOI: 10.1002/elps.200405846
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2 |
Agaton C, Falk R, Hoiden Guthenberg I, Gostring L, Uhlen M, Hober S.
Selective enrichment of monospecific polyclonal antibodies for antibody-based proteomics efforts.
J Chromatogr A 2004 16;1043(1):33-40.
PubMed: 15317410
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1 |
Agaton C, Galli J, Höidén Guthenberg I, Janzon L, Hansson M, Asplund A, Brundell E, Lindberg S, Ruthberg I, Wester K, Wurtz D, Höög C, Lundeberg J, Ståhl S, Pontén F, Uhlén M.
Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues.
Mol Cell Proteomics. 2003 2(6):405-14.
PubMed: 12796447 DOI: 10.1074/mcp.M300022-MCP200
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