Cell atlas - ITM2B - The Human Protein Atlas

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ITM2B

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus
	Vesicles

Human cell
	Golgi Apparatus
	Vesicles

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GENERAL INFORMATION
Gene name	ITM2B
Gene description	Integral membrane protein 2B
Protein class	Disease related genes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus & vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (validated), Vesicles (validated)

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA029292 , HPA071992
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus & vesicles.

Main location

Golgi apparatus (validated), Vesicles (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA029292	A-431	Golgi apparatus
	HPA029292	A-431	Vesicles
	HPA029292	U-251 MG	Golgi apparatus
	HPA029292	U-251 MG	Vesicles
	HPA071992	HaCaT	Golgi apparatus
	HPA071992	HaCaT	Vesicles
	HPA071992	RT4	Golgi apparatus
	HPA071992	RT4	Vesicles
	HPA071992	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	ITM2B (HGNC Symbol)
Synonyms	BRI, BRI2, BRICD2B, E25B, E3-16
Description	Integral membrane protein 2B (HGNC Symbol)
Entrez gene summary	Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Chromosome	13
Cytoband	q14.2
Chromosome location (bp)	48233158 - 48270357
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000136156 (version 83.38)
Entrez gene	9445
UniProt	Q9Y287 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y287
Antibodypedia	ITM2B antibodies

PROTEIN BROWSER

ITM2B-001	ITM2B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITM2B-001 ENSP00000367828 ENST00000378565	Q9Y287 [Direct mapping] Integral membrane protein 2B BRI2, membrane form BRI2 intracellular domain BRI2C, soluble form Bri23 peptide Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0031301 [integral component of organelle membrane] GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	266 aa 30.3 kDa	No	1
ITM2B-003 ENSP00000367811 ENST00000378549	Q9Y287 [Direct mapping] Integral membrane protein 2B BRI2, membrane form BRI2 intracellular domain BRI2C, soluble form Bri23 peptide Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001540 [beta-amyloid binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0007399 [nervous system development] GO:0010008 [endosome membrane] GO:0016020 [membrane] GO:0030660 [Golgi-associated vesicle membrane] GO:0031301 [integral component of organelle membrane] GO:0042985 [negative regulation of amyloid precursor protein biosynthetic process] GO:0043231 [intracellular membrane-bounded organelle] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	160 aa 18.3 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.