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A majority of malignant cells showed moderate to strong cytoplasmic immunoreactivity. Malignant gliomas, lymphomas and melanomas as well as testicular and thyroid cancers were generally negative.
GENE INFORMATION
Gene name
TSPAN6 (HGNC Symbol)
Synonyms
T245, TM4SF6, TSPAN-6
Description
Tetraspanin 6 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]