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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
Enzymes ENZYME proteins Ligase MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000096 [sulfur amino acid metabolic process] GO:0000287 [magnesium ion binding] GO:0004357 [glutamate-cysteine ligase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006534 [cysteine metabolic process] GO:0006536 [glutamate metabolic process] GO:0006749 [glutathione metabolic process] GO:0006750 [glutathione biosynthetic process] GO:0006805 [xenobiotic metabolic process] GO:0006979 [response to oxidative stress] GO:0008637 [apoptotic mitochondrial changes] GO:0009408 [response to heat] GO:0009410 [response to xenobiotic stimulus] GO:0009725 [response to hormone] GO:0016595 [glutamate binding] GO:0017109 [glutamate-cysteine ligase complex] GO:0019852 [L-ascorbic acid metabolic process] GO:0031397 [negative regulation of protein ubiquitination] GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process] GO:0034641 [cellular nitrogen compound metabolic process] GO:0043066 [negative regulation of apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043531 [ADP binding] GO:0044281 [small molecule metabolic process] GO:0045454 [cell redox homeostasis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046685 [response to arsenic-containing substance] GO:0046982 [protein heterodimerization activity] GO:0050662 [coenzyme binding] GO:0050880 [regulation of blood vessel size] GO:0051409 [response to nitrosative stress] GO:0051900 [regulation of mitochondrial depolarization] GO:1901687 [glutathione derivative biosynthetic process] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
