Fields »
ABOUT
HELP
BLOG
RAD52

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 RAD52

Gene description

 RAD52 homolog, DNA repair protein

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles. In addition localized to the plasma membrane.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (approved)

Additional location

 In addition localized to the Plasma membrane (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA028957
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles. In addition localized to the plasma membrane.

Main location

 Nuclear speckles (approved)

Additional location

 Plasma membrane (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA028957 A549 Nuclear speckles
Plasma membrane
HPA028957 CACO-2 Nuclear speckles
HPA028957 U-2 OS Nuclear speckles

GENE INFORMATION

Gene name

 RAD52

Synonyms

Description

 RAD52 homolog, DNA repair protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 912077 - 990053

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000002016 (version 83.38)

Entrez gene

 5893

UniProt

 P43351 (UniProt - Evidence at protein level)

neXtProt

 NX_P43351

Antibodypedia

 RAD52 antibodies

PROTEIN BROWSER
RAD52-001
RAD52-007
RAD52-008
RAD52-012
RAD52-013
RAD52-017
RAD52-018
RAD52-201
RAD52-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAD52-001
ENSP00000351284
ENST00000358495
P43351 [Direct mapping]
DNA repair protein RAD52 homolog
Q5DR82 [Target identity:100%; Query identity:100%]
RAD52 homolog (S. cerevisiae), isoform CRA_c; Rhabdomyosarcoma antigen MU-RMS-40.23; cDNA FLJ77029, highly similar to Homo sapiens RAD52 homolog (S. cerevisiae) (RAD52), transcript variant alpha, mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0016925 [protein sumoylation]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045002 [double-strand break repair via single-strand annealing]
GO:2000819 [regulation of nucleotide-excision repair]
Show all
 418 aa
46.2 kDa 		No 0
RAD52-007
ENSP00000380407
ENST00000397230
E9PF95 [Direct mapping]
DNA repair protein RAD52 homolog
Show all
Predicted intracellular proteins
Show all
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
Show all
 132 aa
14.6 kDa 		No 0
RAD52-008
ENSP00000387901
ENST00000430095
P43351 [Direct mapping]
DNA repair protein RAD52 homolog
Q5DR82 [Target identity:100%; Query identity:100%]
RAD52 homolog (S. cerevisiae), isoform CRA_c; Rhabdomyosarcoma antigen MU-RMS-40.23; cDNA FLJ77029, highly similar to Homo sapiens RAD52 homolog (S. cerevisiae) (RAD52), transcript variant alpha, mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0016925 [protein sumoylation]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0045002 [double-strand break repair via single-strand annealing]
GO:2000819 [regulation of nucleotide-excision repair]
Show all
 418 aa
46.2 kDa 		No 0
RAD52-012
ENSP00000443254
ENST00000544742
P43351 [Direct mapping]
DNA repair protein RAD52 homolog
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0016925 [protein sumoylation]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:2000819 [regulation of nucleotide-excision repair]
Show all
 118 aa
12.9 kDa 		No 0
RAD52-013
ENSP00000438965
ENST00000541619
P43351 [Direct mapping]
DNA repair protein RAD52 homolog
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0016925 [protein sumoylation]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:2000819 [regulation of nucleotide-excision repair]
Show all
 118 aa
12.9 kDa 		No 0
RAD52-017
ENSP00000440486
ENST00000536177
F5GX32 [Direct mapping]
DNA repair protein RAD52 homolog
Show all
Predicted intracellular proteins
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0005634 [nucleus]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0045002 [double-strand break repair via single-strand annealing]
Show all
 301 aa
32.5 kDa 		No 0
RAD52-018
ENSP00000441073
ENST00000542785
F5GX95 [Direct mapping]
DNA repair protein RAD52 homolog
Show all
Predicted intracellular proteins
Show all
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
Show all
 129 aa
14 kDa 		No 0
RAD52-201
ENSP00000445245
ENST00000539046
F5H3Q1 [Direct mapping]
DNA repair protein RAD52 homolog
Show all
Predicted intracellular proteins
Show all
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
Show all
 120 aa
13.2 kDa 		No 0
RAD52-202
ENSP00000440268
ENST00000545564
P43351 [Direct mapping]
DNA repair protein RAD52 homolog
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000730 [DNA recombinase assembly]
GO:0003677 [DNA binding]
GO:0003684 [damaged DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006312 [mitotic recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010792 [DNA double-strand break processing involved in repair via single-strand annealing]
GO:0016925 [protein sumoylation]
GO:0034599 [cellular response to oxidative stress]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:2000819 [regulation of nucleotide-excision repair]
Show all
 226 aa
24.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.