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AOC1

GENERAL INFORMATION

Gene name

 AOC1

Gene description

 Amine oxidase, copper containing 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, endometrial cancer, pancreatic cancer, renal cancer, stomach cancer)
HPA (cell line):Cell line enhanced (CAPAN-2, THP-1)
HPA (normal tissue):Tissue enhanced (placenta, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA031032 , HPA031033
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PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (favourable).
Prostate cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, endometrial cancer, pancreatic cancer, renal cancer, stomach cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Stomach cancer

STAINING SUMMARY
HPA031032
HPA031033

GENE INFORMATION

Gene name

 AOC1 (HGNC Symbol)

Synonyms

 ABP1, DAO

Description

 Amine oxidase, copper containing 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Chromosome

 7

Cytoband

 q36.1

Chromosome location (bp)

 150824627 - 150861504

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000002726 (version 83.38)

Entrez gene

 26

UniProt

 P19801 (UniProt - Evidence at protein level)

neXtProt

 NX_P19801

Antibodypedia

 AOC1 antibodies

PROTEIN BROWSER
AOC1-001
AOC1-002
AOC1-007
AOC1-009
AOC1-010
AOC1-012
AOC1-201
AOC1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AOC1-001
ENSP00000354193
ENST00000360937
P19801 [Direct mapping]
Amiloride-sensitive amine oxidase [copper-containing]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005777 [peroxisome]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0006805 [xenobiotic metabolic process]
GO:0008131 [primary amine oxidase activity]
GO:0008144 [drug binding]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0009308 [amine metabolic process]
GO:0032403 [protein complex binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0035874 [cellular response to copper ion starvation]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0048038 [quinone binding]
GO:0052597 [diamine oxidase activity]
GO:0052598 [histamine oxidase activity]
GO:0052599 [methylputrescine oxidase activity]
GO:0052600 [propane-1,3-diamine oxidase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071280 [cellular response to copper ion]
GO:0071420 [cellular response to histamine]
GO:0071504 [cellular response to heparin]
GO:0097185 [cellular response to azide]
Show all
 751 aa
85.4 kDa 		Yes 0
AOC1-002
ENSP00000411613
ENST00000416793
P19801 [Direct mapping]
Amiloride-sensitive amine oxidase [copper-containing]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005777 [peroxisome]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0006805 [xenobiotic metabolic process]
GO:0008131 [primary amine oxidase activity]
GO:0008144 [drug binding]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0009308 [amine metabolic process]
GO:0032403 [protein complex binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0035874 [cellular response to copper ion starvation]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0048038 [quinone binding]
GO:0052597 [diamine oxidase activity]
GO:0052598 [histamine oxidase activity]
GO:0052599 [methylputrescine oxidase activity]
GO:0052600 [propane-1,3-diamine oxidase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071280 [cellular response to copper ion]
GO:0071420 [cellular response to histamine]
GO:0071504 [cellular response to heparin]
GO:0097185 [cellular response to azide]
Show all
 770 aa
87.2 kDa 		Yes 0
AOC1-007
ENSP00000417392
ENST00000483043
C9J2J4 [Direct mapping]
Amiloride-sensitive amine oxidase [copper-containing]
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0048038 [quinone binding]
GO:0055114 [oxidation-reduction process]
Show all
 337 aa
37.6 kDa 		Yes 0
AOC1-009
ENSP00000418614
ENST00000493429
P19801 [Direct mapping]
Amiloride-sensitive amine oxidase [copper-containing]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005777 [peroxisome]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0006805 [xenobiotic metabolic process]
GO:0008131 [primary amine oxidase activity]
GO:0008144 [drug binding]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0009308 [amine metabolic process]
GO:0032403 [protein complex binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0035874 [cellular response to copper ion starvation]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0048038 [quinone binding]
GO:0052597 [diamine oxidase activity]
GO:0052598 [histamine oxidase activity]
GO:0052599 [methylputrescine oxidase activity]
GO:0052600 [propane-1,3-diamine oxidase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071280 [cellular response to copper ion]
GO:0071420 [cellular response to histamine]
GO:0071504 [cellular response to heparin]
GO:0097185 [cellular response to azide]
Show all
 751 aa
85.4 kDa 		Yes 0
AOC1-010
ENSP00000418328
ENST00000467291
P19801 [Direct mapping]
Amiloride-sensitive amine oxidase [copper-containing]
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004872 [receptor activity]
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005507 [copper ion binding]
GO:0005509 [calcium ion binding]
GO:0005615 [extracellular space]
GO:0005777 [peroxisome]
GO:0005886 [plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0006805 [xenobiotic metabolic process]
GO:0008131 [primary amine oxidase activity]
GO:0008144 [drug binding]
GO:0008201 [heparin binding]
GO:0008270 [zinc ion binding]
GO:0009308 [amine metabolic process]
GO:0032403 [protein complex binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0035874 [cellular response to copper ion starvation]
GO:0042493 [response to drug]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0046677 [response to antibiotic]
GO:0048038 [quinone binding]
GO:0052597 [diamine oxidase activity]
GO:0052598 [histamine oxidase activity]
GO:0052599 [methylputrescine oxidase activity]
GO:0052600 [propane-1,3-diamine oxidase activity]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
GO:0071280 [cellular response to copper ion]
GO:0071420 [cellular response to histamine]
GO:0071504 [cellular response to heparin]
GO:0097185 [cellular response to azide]
Show all
 751 aa
85.4 kDa 		Yes 0
AOC1-012
ENSP00000418557
ENST00000460213
C9J0G8 [Direct mapping]
Amiloride-sensitive amine oxidase [copper-containing]
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0048038 [quinone binding]
GO:0055114 [oxidation-reduction process]
Show all
 249 aa
28.1 kDa 		Yes 0
AOC1-201
ENSP00000481717
ENST00000619575
A0A087WYD8 [Direct mapping]
Amine oxidase
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0048038 [quinone binding]
GO:0055114 [oxidation-reduction process]
Show all
 710 aa
80.5 kDa 		Yes 0
AOC1-202
ENSP00000481520
ENST00000622116
A0A087WY53 [Direct mapping]
Amiloride-sensitive amine oxidase [copper-containing]
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005507 [copper ion binding]
GO:0008131 [primary amine oxidase activity]
GO:0009308 [amine metabolic process]
GO:0048038 [quinone binding]
GO:0055114 [oxidation-reduction process]
Show all
 194 aa
23 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.