Cell atlas - LASP1 - The Human Protein Atlas

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LASP1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Focal adhesion sites
	Plasma membrane

Human cell
	Actin Filaments
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	LASP1
Gene description	LIM and SH3 protein 1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the focal adhesion sites.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cytosol (supported)
Additional location	In addition localized to the Focal adhesion sites (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA012072 , CAB022049
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the focal adhesion sites.

Main location

Plasma membrane (supported), Cytosol (supported)

Additional location

Focal adhesion sites (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA012072	A-431	Plasma membrane
		Focal adhesion sites
		Cytosol
HPA012072	U-2 OS	Plasma membrane
		Focal adhesion sites
		Cytosol
HPA012072	U-251 MG	Plasma membrane
		Focal adhesion sites
		Cytosol
CAB022049	A-431	Golgi apparatus
		Plasma membrane
		Cytosol
CAB022049	U-2 OS	Plasma membrane
CAB022049	U-2 OS	Cytosol
CAB022049	U-251 MG	Plasma membrane
CAB022049	U-251 MG	Cytosol

GENE INFORMATION
Gene name	LASP1 (HGNC Symbol)
Synonyms	Lasp-1, MLN50
Description	LIM and SH3 protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	38869859 - 38921770
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000002834 (version 83.38)
Entrez gene	3927
UniProt	Q14847 (UniProt - Evidence at protein level)
neXtProt	NX_Q14847
Antibodypedia	LASP1 antibodies

PROTEIN BROWSER

LASP1-001	LASP1-002	LASP1-008	LASP1-201	LASP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LASP1-001 ENSP00000325240 ENST00000318008	Q14847 [Direct mapping] LIM and SH3 domain protein 1 A0A024R1S8 [Target identity:100%; Query identity:100%] LIM and SH3 protein 1, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0006811 [ion transport] GO:0008270 [zinc ion binding] GO:0009967 [positive regulation of signal transduction] GO:0015075 [ion transmembrane transporter activity] GO:0030864 [cortical actin cytoskeleton] GO:0034220 [ion transmembrane transport] GO:0051015 [actin filament binding] GO:0070062 [extracellular exosome] Show all	261 aa 29.7 kDa	No	0
LASP1-002 ENSP00000391897 ENST00000419929	C9J9W2 [Direct mapping] LIM and SH3 domain protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		166 aa 19 kDa	No	0
LASP1-008 ENSP00000462564 ENST00000579123	J3KSN1 [Direct mapping] LIM and SH3 domain protein 1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		105 aa 11.4 kDa	No	0
LASP1-201 ENSP00000401048 ENST00000433206	Q14847 [Direct mapping] LIM and SH3 domain protein 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005925 [focal adhesion] GO:0006811 [ion transport] GO:0008270 [zinc ion binding] GO:0009967 [positive regulation of signal transduction] GO:0015075 [ion transmembrane transporter activity] GO:0030864 [cortical actin cytoskeleton] GO:0070062 [extracellular exosome] Show all	205 aa 23.2 kDa	No	0
LASP1-202 ENSP00000392853 ENST00000435347	Q14847 [Direct mapping] LIM and SH3 domain protein 1 A0A024R1S8 [Target identity:100%; Query identity:100%] LIM and SH3 protein 1, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005925 [focal adhesion] GO:0006811 [ion transport] GO:0008270 [zinc ion binding] GO:0009967 [positive regulation of signal transduction] GO:0015075 [ion transmembrane transporter activity] GO:0030864 [cortical actin cytoskeleton] GO:0070062 [extracellular exosome] Show all	261 aa 29.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.