Expression of M6PR in cancer - Summary - The Human Protein Atlas

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M6PR

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	M6PR
Gene description	Mannose-6-phosphate receptor (cation dependent)
Protein class	FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA040445 , CAB034464
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040445	CAB034464

GENE INFORMATION
Gene name	M6PR
Synonyms
Description	Mannose-6-phosphate receptor (cation dependent) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8940363 - 8949955
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000003056 (version 83.38)
Entrez gene	4074
UniProt	P20645 (UniProt - Evidence at protein level)
neXtProt	NX_P20645
Antibodypedia	M6PR antibodies

PROTEIN BROWSER

M6PR-001	M6PR-003	M6PR-004	M6PR-005	M6PR-009	M6PR-010	M6PR-011	M6PR-012	M6PR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
M6PR-001 ENSP00000000412 ENST00000000412	P20645 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0005537 [mannose binding] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005770 [late endosome] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0007165 [signal transduction] GO:0008333 [endosome to lysosome transport] GO:0015578 [mannose transmembrane transporter activity] GO:0015761 [mannose transport] GO:0016020 [membrane] GO:0048471 [perinuclear region of cytoplasm] Show all	277 aa 31 kDa	Yes	1
M6PR-003 ENSP00000439968 ENST00000544245	F5H4U1 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.9 kDa	No	0
M6PR-004 ENSP00000440962 ENST00000543845	F5GXU0 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000323 [lytic vacuole] GO:0005537 [mannose binding] GO:0015578 [mannose transmembrane transporter activity] GO:0015761 [mannose transport] GO:0016021 [integral component of membrane] Show all	109 aa 12.2 kDa	Yes	0
M6PR-005 ENSP00000441030 ENST00000543159	F5GXE0 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000323 [lytic vacuole] GO:0005537 [mannose binding] GO:0015578 [mannose transmembrane transporter activity] GO:0015761 [mannose transport] GO:0016021 [integral component of membrane] Show all	92 aa 10.4 kDa	Yes	0
M6PR-009 ENSP00000444684 ENST00000537621	H0YGT2 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000323 [lytic vacuole] GO:0005537 [mannose binding] GO:0015578 [mannose transmembrane transporter activity] GO:0015761 [mannose transport] GO:0016021 [integral component of membrane] Show all	122 aa 13.3 kDa	No	1
M6PR-010 ENSP00000439070 ENST00000539143	H0YFL0 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.3 kDa	No	0
M6PR-011 ENSP00000437595 ENST00000543704	H0YF90 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000323 [lytic vacuole] GO:0005537 [mannose binding] GO:0015578 [mannose transmembrane transporter activity] GO:0015761 [mannose transport] GO:0016021 [integral component of membrane] Show all	148 aa 16.4 kDa	Yes	1
M6PR-012 ENSP00000441040 ENST00000544193	H0YFY9 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	85 aa 9.4 kDa	No	1
M6PR-201 ENSP00000440488 ENST00000536844	F5GX30 [Direct mapping] Cation-dependent mannose-6-phosphate receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000323 [lytic vacuole] GO:0005537 [mannose binding] GO:0015578 [mannose transmembrane transporter activity] GO:0015761 [mannose transport] GO:0016021 [integral component of membrane] Show all	191 aa 21.5 kDa	Yes	0

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The Human Protein Atlas

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