Cell atlas - SLC7A2 - The Human Protein Atlas

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SLC7A2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SLC7A2
Gene description	Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cell junctions.
RNA cell category	Cell line enhanced (RT4, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported)
Additional location	In addition localized to the Cell Junctions (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA009277
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cell junctions.

Main location

Plasma membrane (supported)

Additional location

Cell Junctions (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA009277	MCF7	Plasma membrane
	HPA009277	U-2 OS	Plasma membrane
	HPA009277	U-2 OS	Cell Junctions

GENE INFORMATION
Gene name	SLC7A2 (HGNC Symbol)
Synonyms	ATRC2, CAT-2, HCAT2
Description	Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Chromosome	8
Cytoband	p22
Chromosome location (bp)	17497088 - 17570573
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000003989 (version 83.38)
Entrez gene	6542
UniProt	P52569 (UniProt - Evidence at protein level)
neXtProt	NX_P52569
Antibodypedia	SLC7A2 antibodies

PROTEIN BROWSER

SLC7A2-001	SLC7A2-002	SLC7A2-003	SLC7A2-201	SLC7A2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC7A2-001 ENSP00000419140 ENST00000494857	P52569 [Direct mapping] Cationic amino acid transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000064 [L-ornithine transmembrane transporter activity] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015181 [arginine transmembrane transporter activity] GO:0015189 [L-lysine transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0097638 [L-arginine import across plasma membrane] GO:1903352 [L-ornithine transmembrane transport] GO:1903401 [L-lysine transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	658 aa 71.7 kDa	No	>9
SLC7A2-002 ENSP00000419873 ENST00000470360	P52569 [Direct mapping] Cationic amino acid transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000064 [L-ornithine transmembrane transporter activity] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015181 [arginine transmembrane transporter activity] GO:0015189 [L-lysine transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0097638 [L-arginine import across plasma membrane] GO:1903352 [L-ornithine transmembrane transport] GO:1903401 [L-lysine transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	697 aa 76 kDa	No	>9
SLC7A2-003 ENSP00000430464 ENST00000522656	P52569 [Direct mapping] Cationic amino acid transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000064 [L-ornithine transmembrane transporter activity] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015181 [arginine transmembrane transporter activity] GO:0015189 [L-lysine transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0097638 [L-arginine import across plasma membrane] GO:1903352 [L-ornithine transmembrane transport] GO:1903401 [L-lysine transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	658 aa 71.7 kDa	No	>9
SLC7A2-201 ENSP00000004531 ENST00000004531	P52569 [Direct mapping] Cationic amino acid transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000064 [L-ornithine transmembrane transporter activity] GO:0002537 [nitric oxide production involved in inflammatory response] GO:0003333 [amino acid transmembrane transport] GO:0005289 [high-affinity arginine transmembrane transporter activity] GO:0005292 [high-affinity lysine transmembrane transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006809 [nitric oxide biosynthetic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015181 [arginine transmembrane transporter activity] GO:0015189 [L-lysine transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015809 [arginine transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042116 [macrophage activation] GO:0043030 [regulation of macrophage activation] GO:0050727 [regulation of inflammatory response] GO:0055085 [transmembrane transport] GO:0061459 [L-arginine transmembrane transporter activity] GO:0097626 [low-affinity L-arginine transmembrane transporter activity] GO:0097627 [high-affinity L-ornithine transmembrane transporter activity] GO:0097638 [L-arginine import across plasma membrane] GO:0097639 [L-lysine import across plasma membrane] GO:0097640 [L-ornithine import across plasma membrane] GO:1902023 [L-arginine transport] GO:1903352 [L-ornithine transmembrane transport] GO:1903401 [L-lysine transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	698 aa 76 kDa	No	>9
SLC7A2-202 ENSP00000381164 ENST00000398090	P52569 [Direct mapping] Cationic amino acid transporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000064 [L-ornithine transmembrane transporter activity] GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006520 [cellular amino acid metabolic process] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015171 [amino acid transmembrane transporter activity] GO:0015174 [basic amino acid transmembrane transporter activity] GO:0015181 [arginine transmembrane transporter activity] GO:0015189 [L-lysine transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0097638 [L-arginine import across plasma membrane] GO:1903352 [L-ornithine transmembrane transport] GO:1903401 [L-lysine transmembrane transport] GO:1990822 [basic amino acid transmembrane transport] Show all	697 aa 76 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.