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A few prostate cancers and one case of lymphoma displayed moderate to strong cytoplasmic and membranous staining. Remaining tumour cells were negative.
Fraction of tumor cells in a few prostate cancers showed moderate membranous positivity. A rare case of mucinous cystadenocarcinoma of ovary displayed moderate cytoplasmic staining. Remaining cancer tissues were negative.
Low grade prostate cancers displayed distinct cytoplasmic positivity while high grade cancers were negative. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
CD38
Synonyms
Description
CD38 molecule (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]