Expression of RBM6 in cancer - Summary - The Human Protein Atlas

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RBM6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RBM6
Gene description	RNA binding motif protein 6
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High and ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA026272 , HPA027164
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), pancreatic cancer (favourable) and renal cancer (unfavourable).
Urothelial cancer p<0.001 Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026272	HPA027164

GENE INFORMATION
Gene name	RBM6 (HGNC Symbol)
Synonyms	3G2, DEF-3, DEF3, g16, NY-LU-12
Description	RNA binding motif protein 6 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	49940007 - 50100045
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000004534 (version 83.38)
Entrez gene	10180
UniProt	P78332 (UniProt - Evidence at protein level)
neXtProt	NX_P78332
Antibodypedia	RBM6 antibodies

PROTEIN BROWSER

RBM6-001	RBM6-006	RBM6-007	RBM6-009	RBM6-010	RBM6-014	RBM6-017	RBM6-019

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBM6-001 ENSP00000266022 ENST00000266022	P78332 [Direct mapping] RNA-binding protein 6 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006396 [RNA processing] GO:0044822 [poly(A) RNA binding] Show all	1123 aa 128.6 kDa	No	0
RBM6-006 ENSP00000393530 ENST00000442092	P78332 [Direct mapping] RNA-binding protein 6 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006396 [RNA processing] GO:0044822 [poly(A) RNA binding] Show all	601 aa 69.2 kDa	No	0
RBM6-007 ENSP00000392939 ENST00000422955	P78332 [Direct mapping] RNA-binding protein 6 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003677 [DNA binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006396 [RNA processing] GO:0044822 [poly(A) RNA binding] Show all	601 aa 69.2 kDa	No	0
RBM6-009 ENSP00000396466 ENST00000443081	E9PGM9 [Direct mapping] RNA-binding protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	991 aa 113.9 kDa	No	0
RBM6-010 ENSP00000389763 ENST00000433811	C9JMC8 [Direct mapping] RNA-binding protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.6 kDa	No	0
RBM6-014 ENSP00000394336 ENST00000446471	C9JSL1 [Direct mapping] RNA-binding protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	156 aa 18.3 kDa	No	0
RBM6-017 ENSP00000403865 ENST00000438912	C9JII0 [Direct mapping] RNA-binding protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	120 aa 13.8 kDa	No	0
RBM6-019 ENSP00000392475 ENST00000421682	C9J250 [Direct mapping] RNA-binding protein 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	119 aa 12.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.